Personal profile
Research Interests
Corneal pathobiology, Keratoconus, Diabetic Keratopathy, Sphingolipids, and 3D bioprinting
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Area of Expertise
Dr Karamichos research aims to discover, develop, and deliver novel therapies for the treatment of corneal trauma, diseases, and dystrophies. Dr Karamichos and team focus part of their work on Keratoconus disease where they are working on novel biomarkers and delineating the role of sex hormones during the onset and progression of the disease. Dr Karamichos is also investigating the role of sphingolipids in corneal wound healing, using complementary in vitro and in vivo models. Other areas of investigation are focused on diabetic keratopathy and the application of bioengineering for corneal transplantation.
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Collaborations and top research areas from the last five years
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The Intimate Interplay Between
Karamichos, D. (PI), Cunningham, R. (CoI) & Nandy, R. (CoI)
1/09/23 → 31/01/27
Project: Research
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A Novel Pathogenic Pathway for
Karamichos, D. (PI) & Nandy, R. (CoI)
1/01/23 → 31/12/27
Project: Research
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Matrix stiffness and serum concentration effects matrix remodelling and ECM regulatory genes of human bone marrow stem cells
Karamichos, D., Skinner, J., Brown, R. & Mudera, V., 2008, In: Journal of Tissue Engineering and Regenerative Medicine. 2, 2-3, p. 97-105 9 p.Research output: Contribution to journal › Article › peer-review
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Chronic intermittent hypoxia modulates corneal fibrotic markers and inflammatory cytokine expression in a sex-dependent manner
Bradshaw, J. L., Vasini, B., Mabry, S., Hefley, B. S., Wilson, E. N., Gardner, J. J., Cunningham, R. L. & Karamichos, D., Jun 2025, In: Experimental eye research. 255, 110358.Research output: Contribution to journal › Article › peer-review
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Arginine supplementation promotes extracellular matrix and metabolic changes in keratoconus
McKay, T. B., Priyadarsini, S., Rowsey, T. & Karamichos, D., Aug 2021, In: Cells. 10, 8, 2076.Research output: Contribution to journal › Article › peer-review
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Unravelling the Impact of Cyclic Mechanical Stretch in Keratoconus—A Transcriptomic Profiling Study
Akoto, T., Cai, J., Nicholas, S., McCord, H., Estes, A. J., Xu, H., Karamichos, D. & Liu, Y., Apr 2023, In: International journal of molecular sciences. 24, 8, 7437.Research output: Contribution to journal › Article › peer-review
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Ablation of Sphingosine Kinase 1 Protects Cornea from Neovascularization in a Mouse Corneal Injury Model
Wilkerson, J. L., Basu, S. K., Stiles, M. A., Prislovsky, A., Grambergs, R. C., Nicholas, S. E., Karamichos, D., Allegood, J. C., Proia, R. L. & Mandal, N., Sep 2022, In: Cells. 11, 18, 2914.Research output: Contribution to journal › Article › peer-review