Zacopride

Tina Machu

doi:10.1016/B978-008055232-3.62872-7

Zacopride

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Zacopride is used in its tritiated form to label 5-HT₃ receptors. It is a competitive antagonist used to label both homomeric 5-HT_3A receptors and heteromeric 5-HT_3A/B receptors. The (S) enantiomer is more selective than the (R) enantiomer. It has been used extensively to assess the roles of the 5-HT₃ receptor in behavioral models, such as drug discrimination, anxiety, and cognition. It has been used to evaluate the role of the 5-HT₃ receptor in emesis and abdominal contractions. © 2007

Original language	English
Title of host publication	xPharm
Subtitle of host publication	The Comprehensive Pharmacology Reference
Publisher	Elsevier Inc.
Pages	1-2
Number of pages	2
ISBN (Print)	9780080552323
DOIs	https://doi.org/10.1016/B978-008055232-3.62872-7
State	Published - 1 Jan 2007

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10.1016/B978-008055232-3.62872-7

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AB - Zacopride is used in its tritiated form to label 5-HT3 receptors. It is a competitive antagonist used to label both homomeric 5-HT3A receptors and heteromeric 5-HT3A/B receptors. The (S) enantiomer is more selective than the (R) enantiomer. It has been used extensively to assess the roles of the 5-HT3 receptor in behavioral models, such as drug discrimination, anxiety, and cognition. It has been used to evaluate the role of the 5-HT3 receptor in emesis and abdominal contractions. © 2007

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Zacopride

Abstract

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