TY - JOUR
T1 - Y chromosome haplotypes reveal prehistorical migrations to the Himalayas
AU - Su, B.
AU - Xiao, C.
AU - Deka, R.
AU - Seielstad, M. T.
AU - Kangwanpong, D.
AU - Xiao, J.
AU - Lu, D.
AU - Underhill, P.
AU - Cavalli-Sforza, L.
AU - Chakraborty, R.
AU - Jin, L.
N1 - Funding Information:
Acknowledgements We thank Dr. William S.-Y. Wang and James Zhu for inspiring comments on the early draft of the manuscript. B.S., R.C., and L.J. were supported by NIH grants. J.X. and D.L. were supported by a grant from National Natural Science Foundation of China.
PY - 2000
Y1 - 2000
N2 - By using 19 Y chromosome biallelic markers and 3 Y chromosome microsatellite markers, we analyzed the genetic structure of 31 indigenous Sino-Tibetan speaking populations (607 individuals) currently residing in East, Southeast, and South Asia. Our results showed that a T to C mutation at locus M122 is highly prevalent in almost all of the Sino-Tibetan populations, implying a strong genetic affinity among populations in the same language family. Furthermore, the extremely high frequency of H8, a haplotype derived from M122C, in the Sino-Tibetan speaking populations in the Himalayas including Tibet and northeast India indicated a strong bottleneck effect that occurred during a westward and then southward migration of the founding population of Tibeto-Burmans. We, therefore, postulate that the ancient people, who lived in the upper-middle Yellow River basin about 10,000 years ago and developed one of the earliest Neolithic cultures in East Asia, were the ancestors of modern Sino-Tibetan populations.
AB - By using 19 Y chromosome biallelic markers and 3 Y chromosome microsatellite markers, we analyzed the genetic structure of 31 indigenous Sino-Tibetan speaking populations (607 individuals) currently residing in East, Southeast, and South Asia. Our results showed that a T to C mutation at locus M122 is highly prevalent in almost all of the Sino-Tibetan populations, implying a strong genetic affinity among populations in the same language family. Furthermore, the extremely high frequency of H8, a haplotype derived from M122C, in the Sino-Tibetan speaking populations in the Himalayas including Tibet and northeast India indicated a strong bottleneck effect that occurred during a westward and then southward migration of the founding population of Tibeto-Burmans. We, therefore, postulate that the ancient people, who lived in the upper-middle Yellow River basin about 10,000 years ago and developed one of the earliest Neolithic cultures in East Asia, were the ancestors of modern Sino-Tibetan populations.
UR - http://www.scopus.com/inward/record.url?scp=17744372852&partnerID=8YFLogxK
U2 - 10.1007/s004390000406
DO - 10.1007/s004390000406
M3 - Article
C2 - 11153912
AN - SCOPUS:17744372852
SN - 0340-6717
VL - 107
SP - 582
EP - 590
JO - Human Genetics
JF - Human Genetics
IS - 6
ER -