Y chromosome haplotypes reveal prehistorical migrations to the Himalayas

B. Su, C. Xiao, R. Deka, M. T. Seielstad, D. Kangwanpong, J. Xiao, D. Lu, P. Underhill, L. Cavalli-Sforza, R. Chakraborty, L. Jin

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Abstract

By using 19 Y chromosome biallelic markers and 3 Y chromosome microsatellite markers, we analyzed the genetic structure of 31 indigenous Sino-Tibetan speaking populations (607 individuals) currently residing in East, Southeast, and South Asia. Our results showed that a T to C mutation at locus M122 is highly prevalent in almost all of the Sino-Tibetan populations, implying a strong genetic affinity among populations in the same language family. Furthermore, the extremely high frequency of H8, a haplotype derived from M122C, in the Sino-Tibetan speaking populations in the Himalayas including Tibet and northeast India indicated a strong bottleneck effect that occurred during a westward and then southward migration of the founding population of Tibeto-Burmans. We, therefore, postulate that the ancient people, who lived in the upper-middle Yellow River basin about 10,000 years ago and developed one of the earliest Neolithic cultures in East Asia, were the ancestors of modern Sino-Tibetan populations.

Original languageEnglish
Pages (from-to)582-590
Number of pages9
JournalHuman Genetics
Volume107
Issue number6
DOIs
StatePublished - 1 Jan 2000

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Y Chromosome
Haplotypes
Population
Genetic Markers
Tibet
Southeastern Asia
Chromosomes, Human, Pair 3
Far East
Genetic Structures
Rivers
Microsatellite Repeats
India
Language
Mutation

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Su, B., Xiao, C., Deka, R., Seielstad, M. T., Kangwanpong, D., Xiao, J., ... Jin, L. (2000). Y chromosome haplotypes reveal prehistorical migrations to the Himalayas. Human Genetics, 107(6), 582-590. https://doi.org/10.1007/s004390000406
Su, B. ; Xiao, C. ; Deka, R. ; Seielstad, M. T. ; Kangwanpong, D. ; Xiao, J. ; Lu, D. ; Underhill, P. ; Cavalli-Sforza, L. ; Chakraborty, R. ; Jin, L. / Y chromosome haplotypes reveal prehistorical migrations to the Himalayas. In: Human Genetics. 2000 ; Vol. 107, No. 6. pp. 582-590.
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Su, B, Xiao, C, Deka, R, Seielstad, MT, Kangwanpong, D, Xiao, J, Lu, D, Underhill, P, Cavalli-Sforza, L, Chakraborty, R & Jin, L 2000, 'Y chromosome haplotypes reveal prehistorical migrations to the Himalayas', Human Genetics, vol. 107, no. 6, pp. 582-590. https://doi.org/10.1007/s004390000406

Y chromosome haplotypes reveal prehistorical migrations to the Himalayas. / Su, B.; Xiao, C.; Deka, R.; Seielstad, M. T.; Kangwanpong, D.; Xiao, J.; Lu, D.; Underhill, P.; Cavalli-Sforza, L.; Chakraborty, R.; Jin, L.

In: Human Genetics, Vol. 107, No. 6, 01.01.2000, p. 582-590.

Research output: Contribution to journalArticle

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AU - Su, B.

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AU - Deka, R.

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AU - Xiao, J.

AU - Lu, D.

AU - Underhill, P.

AU - Cavalli-Sforza, L.

AU - Chakraborty, R.

AU - Jin, L.

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AB - By using 19 Y chromosome biallelic markers and 3 Y chromosome microsatellite markers, we analyzed the genetic structure of 31 indigenous Sino-Tibetan speaking populations (607 individuals) currently residing in East, Southeast, and South Asia. Our results showed that a T to C mutation at locus M122 is highly prevalent in almost all of the Sino-Tibetan populations, implying a strong genetic affinity among populations in the same language family. Furthermore, the extremely high frequency of H8, a haplotype derived from M122C, in the Sino-Tibetan speaking populations in the Himalayas including Tibet and northeast India indicated a strong bottleneck effect that occurred during a westward and then southward migration of the founding population of Tibeto-Burmans. We, therefore, postulate that the ancient people, who lived in the upper-middle Yellow River basin about 10,000 years ago and developed one of the earliest Neolithic cultures in East Asia, were the ancestors of modern Sino-Tibetan populations.

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Su B, Xiao C, Deka R, Seielstad MT, Kangwanpong D, Xiao J et al. Y chromosome haplotypes reveal prehistorical migrations to the Himalayas. Human Genetics. 2000 Jan 1;107(6):582-590. https://doi.org/10.1007/s004390000406