TY - JOUR
T1 - Y-chromosome evidence of southern origin of the East Asian-specific haplogroup O3-M122
AU - Shi, Hong
AU - Dong, Yong Li
AU - Wen, Bo
AU - Xiao, Chun Jie
AU - Underbill, Peter A.
AU - Shen, Pei Dong
AU - Chakraborty, Ranajit
AU - Jin, Li
AU - Su, Bing
N1 - Funding Information:
We are thankful to the technical help of Xiao-na Fan and Yi-Chuan Yu. This study was supported by grants from the Chinese Academy of Sciences (KSCX2-SW-121), the National Natural Science Foundation of China (30370755 and 30440018), the Natural Science Foundation of Yunnan Province of China, and the National 973 Project of China (2006CB701506).
PY - 2005/9
Y1 - 2005/9
N2 - The prehistoric peopling of East Asia by modern humans remains controversial with respect to early population migrations. Here, we present a systematic sampling and genetic screening of an East Asian-specific Y-chromosome haplogroup (O3-M122) in 2,332 individuals from diverse East Asian populations. Our results indicate that the O3-M122 lineage is dominant in East Asian populations, with an average frequency of 44.3%. The microsatellite data show that the O3-M122 haplotypes in southern East Asia are more diverse than those in northern East Asia, suggesting a southern origin of the O3-M122 mutation. It was estimated that the early northward migration of the O3-M122 lineages in East Asia occurred ∼25,000-30,000 years ago, consistent with the fossil records of modern humans in East Asia.
AB - The prehistoric peopling of East Asia by modern humans remains controversial with respect to early population migrations. Here, we present a systematic sampling and genetic screening of an East Asian-specific Y-chromosome haplogroup (O3-M122) in 2,332 individuals from diverse East Asian populations. Our results indicate that the O3-M122 lineage is dominant in East Asian populations, with an average frequency of 44.3%. The microsatellite data show that the O3-M122 haplotypes in southern East Asia are more diverse than those in northern East Asia, suggesting a southern origin of the O3-M122 mutation. It was estimated that the early northward migration of the O3-M122 lineages in East Asia occurred ∼25,000-30,000 years ago, consistent with the fossil records of modern humans in East Asia.
UR - http://www.scopus.com/inward/record.url?scp=23944444249&partnerID=8YFLogxK
U2 - 10.1086/444436
DO - 10.1086/444436
M3 - Article
C2 - 16080116
AN - SCOPUS:23944444249
VL - 77
SP - 408
EP - 419
JO - American Journal of Human Genetics
JF - American Journal of Human Genetics
SN - 0002-9297
IS - 3
ER -