XTRPC1-dependent chemotropic guidance of neuronal growth cones

Sangwoo Shim, Eyleen L. Goh, Shaoyu Ge, Kurt Sailor, Joseph P. Yuan, H. Llewelyn Roderick, Martin D. Bootman, Paul F. Worley, Hongjun Song, Guo Li Ming

Research output: Contribution to journalArticleResearchpeer-review

133 Citations (Scopus)

Abstract

Calcium arising through release from intracellular stores and from influx across the plasma membrane is essential for signalling by specific guidance cues and by factors that inhibit axon regeneration. The mediators of calcium influx in these cases are largely unknown. Transient receptor potential channels (TRPCs) belong to a superfamily of Ca2+-permeable, receptor-operated channels that have important roles in sensing and responding to changes in the local environment. Here we report that XTRPC1, a Xenopus homolog of mammalian TRPC1, is required for proper growth cone turning responses of Xenopus spinal neurons to microscopic gradients of netrin-1, brain-derived neurotrophic factor and myelin-associated glycoprotein, but not to semaphorin 3A. Furthermore, XTRPC1 is required for midline guidance of axons of commissural interneurons in the developing Xenopus spinal cord. Thus, members of the TRPC family may serve as a key mediator for the Ca2+ influx that regulates axon guidance during development and inhibits axon regeneration in adulthood.

Original languageEnglish
Pages (from-to)730-735
Number of pages6
JournalNature Neuroscience
Volume8
Issue number6
DOIs
StatePublished - 1 Jun 2005

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Growth Cones
Xenopus
Transient Receptor Potential Channels
Axons
Regeneration
Semaphorin-3A
Myelin-Associated Glycoprotein
Calcium
Brain-Derived Neurotrophic Factor
Cues
Spinal Cord
Cell Membrane
Neurons
Axon Guidance

Cite this

Shim, S., Goh, E. L., Ge, S., Sailor, K., Yuan, J. P., Roderick, H. L., ... Ming, G. L. (2005). XTRPC1-dependent chemotropic guidance of neuronal growth cones. Nature Neuroscience, 8(6), 730-735. https://doi.org/10.1038/nn1459
Shim, Sangwoo ; Goh, Eyleen L. ; Ge, Shaoyu ; Sailor, Kurt ; Yuan, Joseph P. ; Roderick, H. Llewelyn ; Bootman, Martin D. ; Worley, Paul F. ; Song, Hongjun ; Ming, Guo Li. / XTRPC1-dependent chemotropic guidance of neuronal growth cones. In: Nature Neuroscience. 2005 ; Vol. 8, No. 6. pp. 730-735.
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Shim, S, Goh, EL, Ge, S, Sailor, K, Yuan, JP, Roderick, HL, Bootman, MD, Worley, PF, Song, H & Ming, GL 2005, 'XTRPC1-dependent chemotropic guidance of neuronal growth cones', Nature Neuroscience, vol. 8, no. 6, pp. 730-735. https://doi.org/10.1038/nn1459

XTRPC1-dependent chemotropic guidance of neuronal growth cones. / Shim, Sangwoo; Goh, Eyleen L.; Ge, Shaoyu; Sailor, Kurt; Yuan, Joseph P.; Roderick, H. Llewelyn; Bootman, Martin D.; Worley, Paul F.; Song, Hongjun; Ming, Guo Li.

In: Nature Neuroscience, Vol. 8, No. 6, 01.06.2005, p. 730-735.

Research output: Contribution to journalArticleResearchpeer-review

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Shim S, Goh EL, Ge S, Sailor K, Yuan JP, Roderick HL et al. XTRPC1-dependent chemotropic guidance of neuronal growth cones. Nature Neuroscience. 2005 Jun 1;8(6):730-735. https://doi.org/10.1038/nn1459