Working towards implementation of whole genome mitochondrial DNA sequencing into routine casework

Jennifer D. Churchill; Dixie Peters; Christina Capt; Christina Strobl; Walther Parson; Bruce Budowle

doi:10.1016/j.fsigss.2017.09.167

Working towards implementation of whole genome mitochondrial DNA sequencing into routine casework

Jennifer D. Churchill, Dixie Peters, Christina Capt, Christina Strobl, Walther Parson, Bruce Budowle

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Massively parallel sequencing (MPS) technologies offer opportunities to expand forensic mitochondrial DNA (mtDNA) typing capabilities affording higher resolution, an increase in discrimination power, and potentially enabling mixture interpretation. Additionally, improvements to MPS technologies and workflows have made implementation into forensic genetic laboratories increasingly more feasible. Following initial successful studies with the Precision ID mtDNA Whole Genome Panel, the process of internal validation and implementation of whole genome mtDNA sequencing began in our Missing Persons and Forensic Casework Units.

Original language	English
Pages (from-to)	e388-e389
Journal	Forensic Science International: Genetics Supplement Series
Volume	6
DOIs	https://doi.org/10.1016/j.fsigss.2017.09.167
State	Published - Dec 2017

Keywords

Implementation
Ion S5
Massively parallel sequencing
Mitochondrial DNA

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10.1016/j.fsigss.2017.09.167

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title = "Working towards implementation of whole genome mitochondrial DNA sequencing into routine casework",

abstract = "Massively parallel sequencing (MPS) technologies offer opportunities to expand forensic mitochondrial DNA (mtDNA) typing capabilities affording higher resolution, an increase in discrimination power, and potentially enabling mixture interpretation. Additionally, improvements to MPS technologies and workflows have made implementation into forensic genetic laboratories increasingly more feasible. Following initial successful studies with the Precision ID mtDNA Whole Genome Panel, the process of internal validation and implementation of whole genome mtDNA sequencing began in our Missing Persons and Forensic Casework Units.",

keywords = "Implementation, Ion S5, Massively parallel sequencing, Mitochondrial DNA",

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doi = "10.1016/j.fsigss.2017.09.167",

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AU - Churchill, Jennifer D.

AU - Peters, Dixie

AU - Capt, Christina

AU - Strobl, Christina

AU - Parson, Walther

AU - Budowle, Bruce

N1 - Funding Information: This work was supported in part by award no. 2016-DN-BX-K001 , awarded by the National Institute of Justice, Office of Justice Programs, U.S. Department of Justice . The opinions, findings, and conclusions or recommendations expressed in this publication are those of the authors and do not necessarily reflect those of the U.S. Department of Justice. Publisher Copyright: © 2017 Elsevier B.V.

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Working towards implementation of whole genome mitochondrial DNA sequencing into routine casework

Abstract

Keywords

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