Withdrawal from morphine generalizes to a pentylenetetrazol stimulus

Michael Oglesby, C. M. Harris, J. D. Lane, H. Lal

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Rats trained to discriminate pentylenetetrazol (PTZ) from saline in a two-lever food-reinforced operant task were given a three-day course of morphine, 15 to 45 mg/kg tid, ip. On the third day naloxone produced dose-dependent generalization to the PTZ stimulus, with 66% of subjects selecting the PTZ lever after the highest dose (0.32 mg/kg). Following termination of morphine injections, generalization of spontaneous withdrawal was tested. Approximately 50% of subjects selected the PTZ lever at 24 and 48 hrs after the last morphine, and by 96 hrs the percentage of subjects selecting the PTZ lever had dropped to 11%. Rats that chose the PTZ lever at 48 hrs were given diazepam, 5.0 mg/kg, which blocked the PTZ-like stimulus. These data demonstrate that morphine withdrawal produces a stimulus with PTZ-like characteristics which can be blocked by an anxiolytic, and they suggest that the PTZ discrimination may have general utility for investigating drug dependence and withdrawal in animals.

Original languageEnglish
Pages (from-to)37-40
Number of pages4
JournalNeuropeptides
Volume5
Issue number1-3
DOIs
StatePublished - 1 Jan 1984

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Pentylenetetrazole
Morphine
Anti-Anxiety Agents
Diazepam
Naloxone
Substance-Related Disorders
Food
Injections

Cite this

Oglesby, Michael ; Harris, C. M. ; Lane, J. D. ; Lal, H. / Withdrawal from morphine generalizes to a pentylenetetrazol stimulus. In: Neuropeptides. 1984 ; Vol. 5, No. 1-3. pp. 37-40.
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Withdrawal from morphine generalizes to a pentylenetetrazol stimulus. / Oglesby, Michael; Harris, C. M.; Lane, J. D.; Lal, H.

In: Neuropeptides, Vol. 5, No. 1-3, 01.01.1984, p. 37-40.

Research output: Contribution to journalArticle

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