TY - JOUR
T1 - Whither goest the RGS proteins?
AU - Siderovski, David P.
AU - Strockbine, Bentley
AU - Behe, Cynthia I.
N1 - Funding Information:
We would like to thank our Toronto colleagues (Sudha Arya, Greg Brothers, Carol Anne Brothers, Stephen Chung, Harry Elsholtz, Joan Mangion, Jane McGlade, Susan Siderovski, Christian Smith, Bryan Snow, Vuk Stambolic) for their support in our continuing journey. Much thanks also to Laurie Betts, Greg Brothers, Jane McGlade, María Diversé-Pierluissi, and John Sondek for critical appraisal of this review. Our work is supported in part by the National Institutes of Health grant AA11605.
PY - 1999
Y1 - 1999
N2 - Studies of the desensitization of G protein-coupled signal transduction have led to the discovery of a family of guanosine triphosphatase-activating proteins (GAPs) for heterotrimeric G protein alpha subunits the 'regulator of G protein signaling' or RGS proteins. In considering both documented and potential functions of several RGS protein family members with demonstrable multidomain compositions (p115RhoGEF, PDZRhoGEF, Axin, Axil/Conductin, D- AKAP2, the G protein-coupled receptor kinases [GRKs], the DEP/GGL/RGS subfamily [RGS6, RGS7, RGS9, RGS 11], and RGS 12), this review explores the shift in our appreciation of the RGS proteins from unidimensional desensitizing agents to multifocal signal transduction regulators.
AB - Studies of the desensitization of G protein-coupled signal transduction have led to the discovery of a family of guanosine triphosphatase-activating proteins (GAPs) for heterotrimeric G protein alpha subunits the 'regulator of G protein signaling' or RGS proteins. In considering both documented and potential functions of several RGS protein family members with demonstrable multidomain compositions (p115RhoGEF, PDZRhoGEF, Axin, Axil/Conductin, D- AKAP2, the G protein-coupled receptor kinases [GRKs], the DEP/GGL/RGS subfamily [RGS6, RGS7, RGS9, RGS 11], and RGS 12), this review explores the shift in our appreciation of the RGS proteins from unidimensional desensitizing agents to multifocal signal transduction regulators.
KW - Desensitization, effector proteins
KW - GGL
KW - GoLoco
KW - PDZ
KW - PTB
KW - RGS
KW - Regulators of G protein signaling
KW - Scaffold proteins
KW - Signal transduction
UR - http://www.scopus.com/inward/record.url?scp=0032863252&partnerID=8YFLogxK
U2 - 10.1080/10409239991209273
DO - 10.1080/10409239991209273
M3 - Review article
C2 - 10517644
AN - SCOPUS:0032863252
SN - 1040-9238
VL - 34
SP - 215
EP - 251
JO - Critical Reviews in Biochemistry and Molecular Biology
JF - Critical Reviews in Biochemistry and Molecular Biology
IS - 4
ER -