Whither goest the RGS proteins?

David P. Siderovski; Bentley Strockbine; Cynthia I. Behe

doi:10.1080/10409239991209273

Whither goest the RGS proteins?

David P. Siderovski, Bentley Strockbine, Cynthia I. Behe

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Abstract

Studies of the desensitization of G protein-coupled signal transduction have led to the discovery of a family of guanosine triphosphatase-activating proteins (GAPs) for heterotrimeric G protein alpha subunits the 'regulator of G protein signaling' or RGS proteins. In considering both documented and potential functions of several RGS protein family members with demonstrable multidomain compositions (p115RhoGEF, PDZRhoGEF, Axin, Axil/Conductin, D- AKAP2, the G protein-coupled receptor kinases [GRKs], the DEP/GGL/RGS subfamily [RGS6, RGS7, RGS9, RGS 11], and RGS 12), this review explores the shift in our appreciation of the RGS proteins from unidimensional desensitizing agents to multifocal signal transduction regulators.

Original language	English
Pages (from-to)	215-251
Number of pages	37
Journal	Critical Reviews in Biochemistry and Molecular Biology
Volume	34
Issue number	4
DOIs	https://doi.org/10.1080/10409239991209273
State	Published - 1999

Keywords

Desensitization, effector proteins
GGL
GoLoco
PDZ
PTB
RGS
Regulators of G protein signaling
Scaffold proteins
Signal transduction

Access to Document

10.1080/10409239991209273

Cite this

@article{72925ec44f4f47238a55569e57a4ffd5,

title = "Whither goest the RGS proteins?",

abstract = "Studies of the desensitization of G protein-coupled signal transduction have led to the discovery of a family of guanosine triphosphatase-activating proteins (GAPs) for heterotrimeric G protein alpha subunits the 'regulator of G protein signaling' or RGS proteins. In considering both documented and potential functions of several RGS protein family members with demonstrable multidomain compositions (p115RhoGEF, PDZRhoGEF, Axin, Axil/Conductin, D- AKAP2, the G protein-coupled receptor kinases [GRKs], the DEP/GGL/RGS subfamily [RGS6, RGS7, RGS9, RGS 11], and RGS 12), this review explores the shift in our appreciation of the RGS proteins from unidimensional desensitizing agents to multifocal signal transduction regulators.",

keywords = "Desensitization, effector proteins, GGL, GoLoco, PDZ, PTB, RGS, Regulators of G protein signaling, Scaffold proteins, Signal transduction",

author = "Siderovski, {David P.} and Bentley Strockbine and Behe, {Cynthia I.}",

note = "Funding Information: We would like to thank our Toronto colleagues (Sudha Arya, Greg Brothers, Carol Anne Brothers, Stephen Chung, Harry Elsholtz, Joan Mangion, Jane McGlade, Susan Siderovski, Christian Smith, Bryan Snow, Vuk Stambolic) for their support in our continuing journey. Much thanks also to Laurie Betts, Greg Brothers, Jane McGlade, Mar{\'i}a Divers{\'e}-Pierluissi, and John Sondek for critical appraisal of this review. Our work is supported in part by the National Institutes of Health grant AA11605.",

year = "1999",

doi = "10.1080/10409239991209273",

language = "English",

volume = "34",

pages = "215--251",

journal = "Critical Reviews in Biochemistry and Molecular Biology",

issn = "1040-9238",