What is the outcome of targeted tuberculosis screening based on universal genotyping and location?

Patrick K. Moonan, Joseph Oppong, Behzad Sahbazian, Karan P. Singh, Raghbir Sandhu, Gerry Drewyer, Terry LaFon, Marco Marruffo, Teresa N. Quitugua, Charles Wallace, Stephen Weis

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33 Scopus citations

Abstract

Rationale and Objectives: Identifying and treating persons with latent tuberculosis (TB) infection (LTBI) at high risk for developing TB is part of the current TB elimination strategy. There are no specific criteria, other than medical risks, to designate groups as high risk for developing TB. We hypothesized that, if location-based screenings were done in communities where persons with genotypically clustered Mycobacterium tuberculosis resided, then persons with LTBI from recent transmission and with undiagnosed TB could be identified. Methods: Location-based TB screenings were done in partnership with multiple community-based organizations using resources previously used for other types of screening. Main Results: Location-based screenings identified one person with TB for every 83 screened, and one person with LTBI for every five screened. The yield of this targeted screening program for discovering persons with TB and LTBI exceeded what would be expected from nontargeted screening in a county with a TB incidence of 5.7 per 100,000 population. Conclusions: Genotyping combined with geographic information systems analysis can potentially be used to define high-risk status and to define areas for location-based TB screenings.

Original languageEnglish
Pages (from-to)599-604
Number of pages6
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume174
Issue number5
DOIs
StatePublished - 1 Sep 2006

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Keywords

  • Genotyping
  • Location-based screening
  • Mycobacterium tuberculosis

Cite this

Moonan, P. K., Oppong, J., Sahbazian, B., Singh, K. P., Sandhu, R., Drewyer, G., LaFon, T., Marruffo, M., Quitugua, T. N., Wallace, C., & Weis, S. (2006). What is the outcome of targeted tuberculosis screening based on universal genotyping and location? American Journal of Respiratory and Critical Care Medicine, 174(5), 599-604. https://doi.org/10.1164/rccm.200512-1977OC