TY - GEN
T1 - Web-enabled classification of SNPs for genome-wide association studies
AU - Tendulkar, Abhijit R.
AU - Stojanovic, Nikola
AU - Barber, Robert
PY - 2008
Y1 - 2008
N2 - Whole genome association studies of the genetic under-pinnings of complex phenotypes, and human diseases in particular, have been steadily gaining momentum over the past several years. Yet, the number of polymorphic sites in the human genome, including, but not limited to, Single Nucleotide Polymorphisms (SNPs) is so large that identifying the combination of these few that have a significant effect on the condition of interest remains an overwhelming task. In this manuscript we present a new networked solution, and a program GeneNAB implementing it, to the computational identification and ranking of SNPs likely to be relevant for the phenotype of interest, genome-wide. We expect that the output of this program will be useful to guide further laboratory and clinical studies of these SNPs.
AB - Whole genome association studies of the genetic under-pinnings of complex phenotypes, and human diseases in particular, have been steadily gaining momentum over the past several years. Yet, the number of polymorphic sites in the human genome, including, but not limited to, Single Nucleotide Polymorphisms (SNPs) is so large that identifying the combination of these few that have a significant effect on the condition of interest remains an overwhelming task. In this manuscript we present a new networked solution, and a program GeneNAB implementing it, to the computational identification and ranking of SNPs likely to be relevant for the phenotype of interest, genome-wide. We expect that the output of this program will be useful to guide further laboratory and clinical studies of these SNPs.
UR - http://www.scopus.com/inward/record.url?scp=62449095810&partnerID=8YFLogxK
U2 - 10.1109/ICIT.2008.65
DO - 10.1109/ICIT.2008.65
M3 - Conference contribution
AN - SCOPUS:62449095810
SN - 9780769535135
T3 - Proceedings - 11th International Conference on Information Technology, ICIT 2008
SP - 112
EP - 117
BT - Proceedings - 11th International Conference on Information Technology, ICIT 2008
Y2 - 17 December 2008 through 20 December 2008
ER -