Wearable Devices for Single-Cell Sensing and Transfection

Lingqian Chang, Yu Chieh Wang, Faheem Ershad, Ruiguo Yang, Cunjiang Yu, Yubo Fan

Research output: Contribution to journalReview article

4 Scopus citations

Abstract

Wearable healthcare devices are mainly used for biosensing and transdermal delivery. Recent advances in wearable biosensors allow for long-term and real-time monitoring of physiological conditions at a cellular resolution. Transdermal drug delivery systems have been further scaled down, enabling wide selections of cargo, from natural molecules (e.g., insulin and glucose) to bioengineered molecules (e.g., nanoparticles). Some emerging nanopatches show promise for precise single-cell gene transfection in vivo and have advantages over conventional tools in terms of delivery efficiency, safety, and controllability of delivered dose. In this review, we discuss recent technical advances in wearable micro/nano devices with unique capabilities or potential for single-cell biosensing and transfection in the skin or other organs, and suggest future directions for these fields.

Original languageEnglish
Pages (from-to)1175-1188
Number of pages14
JournalTrends in Biotechnology
Volume37
Issue number11
DOIs
StatePublished - Nov 2019

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Keywords

  • biosensors
  • drug delivery
  • gene transfection
  • single cell
  • wearable electronics

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