TY - JOUR
T1 - Volume loading augments cutaneous vasodilatation and cardiac output of heat stressed older adults
AU - Gagnon, Daniel
AU - Romero, Steven A.
AU - Ngo, Hai
AU - Sarma, Satyam
AU - Cornwell, William K.
AU - Poh, Paula Y.S.
AU - Stoller, Douglas
AU - Levine, Benjamin D.
AU - Crandall, Craig G.
N1 - Funding Information:
National Institutes of Health (GM-068865), Department of Defense (W81XWH-12-1-0152) and Research Endowment Grant from the American College of Sports Medicine Foundation. D.G. was supported by a Postdoctoral Fellowship from the Natural Sciences and Engineering Research Council of Canada. W.K.C. is supported by an NIH/NHLBI mentored patient-oriented research career development award (no. 1K23HL132048-01).
Publisher Copyright:
© 2017 The Authors. The Journal of Physiology © 2017 The Physiological Society
PY - 2017/10/15
Y1 - 2017/10/15
N2 - Key points: Age-related changes in cutaneous microvascular and cardiac functions limit the extent of cutaneous vasodilatation and the increase in cardiac output that healthy older adults can achieve during passive heat stress. However, it is unclear if these age-related changes in microvascular and cardiac functions maximally restrain the levels of cutaneous vasodilatation and cardiac output that healthy older adults can achieve during heat stress. We observed that rapid volume loading, performed during passive heat stress, augments both cutaneous vasodilatation and cardiac output in healthy older humans. These findings demonstrate that the microcirculation of healthy aged skin can further dilate during passive heat exposure, despite peripheral limitations to vasodilatation. Furthermore, healthy older humans can augment cardiac output when cardiac pre-load is increased during heat stress. Abstract: Primary ageing markedly attenuates cutaneous vasodilatation and the increase in cardiac output during passive heating. However, it remains unclear if these responses are maximally restrained by age-related changes in cutaneous microvascular and cardiac functions. We hypothesized that rapid volume loading performed during heat stress would increase cardiac output in older adults without parallel increases in cutaneous vasodilatation. Twelve young (Y: 26 ± 5 years) and ten older (O: 69 ± 3 years) healthy adults were passively heated until core temperature increased by 1.5°C. Cardiac output (thermodilution), forearm vascular conductance (FVC, venous occlusion plethysmography) and cutaneous vascular conductance (CVC, laser-Doppler) were measured before and after rapid infusion of warmed saline (15 mL kg−1, ∼7 min). While heat stressed, but prior to saline infusion, cardiac output (O: 6.8 ± 0.4 vs. Y: 9.4 ± 0.6 L min−1), FVC (O: 0.08 ± 0.01 vs. Y: 0.17 ± 0.02 mL (100 mL min−1 mmHg−1)−1), and CVC (O: 1.29 ± 0.34 vs. Y: 1.93 ± 0.30 units mmHg−1) were lower in older adults (all P < 0.01). Rapid saline infusion increased cardiac output (O: +1.9 ± 0.3, Y: +1.8 ± 0.7 L min−1), FVC (O: +0.015 ± 0.007, Y: +0.048 ± 0.013 mL (100 mL min−1 mmHg−1)−1), and CVC (O: +0.28 ± 0.10, Y: +0.29 ± 0.16 units mmHg−1) in both groups (all P < 0.01). The absolute increase in cardiac output and CVC were similar between groups, whereas FVC increased to a greater extent in young adults (P < 0.01). These results demonstrate that healthy older adults can achieve greater levels of cutaneous vasodilatation and cardiac output during passive heating.
AB - Key points: Age-related changes in cutaneous microvascular and cardiac functions limit the extent of cutaneous vasodilatation and the increase in cardiac output that healthy older adults can achieve during passive heat stress. However, it is unclear if these age-related changes in microvascular and cardiac functions maximally restrain the levels of cutaneous vasodilatation and cardiac output that healthy older adults can achieve during heat stress. We observed that rapid volume loading, performed during passive heat stress, augments both cutaneous vasodilatation and cardiac output in healthy older humans. These findings demonstrate that the microcirculation of healthy aged skin can further dilate during passive heat exposure, despite peripheral limitations to vasodilatation. Furthermore, healthy older humans can augment cardiac output when cardiac pre-load is increased during heat stress. Abstract: Primary ageing markedly attenuates cutaneous vasodilatation and the increase in cardiac output during passive heating. However, it remains unclear if these responses are maximally restrained by age-related changes in cutaneous microvascular and cardiac functions. We hypothesized that rapid volume loading performed during heat stress would increase cardiac output in older adults without parallel increases in cutaneous vasodilatation. Twelve young (Y: 26 ± 5 years) and ten older (O: 69 ± 3 years) healthy adults were passively heated until core temperature increased by 1.5°C. Cardiac output (thermodilution), forearm vascular conductance (FVC, venous occlusion plethysmography) and cutaneous vascular conductance (CVC, laser-Doppler) were measured before and after rapid infusion of warmed saline (15 mL kg−1, ∼7 min). While heat stressed, but prior to saline infusion, cardiac output (O: 6.8 ± 0.4 vs. Y: 9.4 ± 0.6 L min−1), FVC (O: 0.08 ± 0.01 vs. Y: 0.17 ± 0.02 mL (100 mL min−1 mmHg−1)−1), and CVC (O: 1.29 ± 0.34 vs. Y: 1.93 ± 0.30 units mmHg−1) were lower in older adults (all P < 0.01). Rapid saline infusion increased cardiac output (O: +1.9 ± 0.3, Y: +1.8 ± 0.7 L min−1), FVC (O: +0.015 ± 0.007, Y: +0.048 ± 0.013 mL (100 mL min−1 mmHg−1)−1), and CVC (O: +0.28 ± 0.10, Y: +0.29 ± 0.16 units mmHg−1) in both groups (all P < 0.01). The absolute increase in cardiac output and CVC were similar between groups, whereas FVC increased to a greater extent in young adults (P < 0.01). These results demonstrate that healthy older adults can achieve greater levels of cutaneous vasodilatation and cardiac output during passive heating.
KW - Ageing
KW - Skin blood flow
KW - Sweat
KW - Temperature
KW - Vasodilatation
KW - cardiac output
UR - http://www.scopus.com/inward/record.url?scp=85030094066&partnerID=8YFLogxK
U2 - 10.1113/JP274742
DO - 10.1113/JP274742
M3 - Article
C2 - 28833129
AN - SCOPUS:85030094066
SN - 0022-3751
VL - 595
SP - 6489
EP - 6498
JO - Journal of Physiology
JF - Journal of Physiology
IS - 20
ER -