TY - JOUR
T1 - Vive la résistance! The role of inspiratory resistance breathing on cerebral blood flow
AU - Rickards, Caroline A.
N1 - Publisher Copyright:
© 2018 Elsevier B.V.
PY - 2019/7
Y1 - 2019/7
N2 - Prolonging the therapeutic window for treatment is imperative for survival from a multitude of life-threatening events such as hemorrhage, cardiac arrest, and stroke. Inspiratory resistance breathing is a therapeutic approach that augments the reduction in intrathoracic and intracranial pressure during inspiration, facilitating improvements in vital organ perfusion under conditions of ischemia, such as blood loss and cardiac arrest. In this review a series of studies will be presented assessing the role of inspiratory resistance breathing on responses of cerebral blood flow and cerebral tissue oxygenation under conditions of cardiac arrest and blood loss in animal models, and simulated hemorrhage in humans. Knowledge gaps in this field of investigation will be presented, and future research directions will be discussed.
AB - Prolonging the therapeutic window for treatment is imperative for survival from a multitude of life-threatening events such as hemorrhage, cardiac arrest, and stroke. Inspiratory resistance breathing is a therapeutic approach that augments the reduction in intrathoracic and intracranial pressure during inspiration, facilitating improvements in vital organ perfusion under conditions of ischemia, such as blood loss and cardiac arrest. In this review a series of studies will be presented assessing the role of inspiratory resistance breathing on responses of cerebral blood flow and cerebral tissue oxygenation under conditions of cardiac arrest and blood loss in animal models, and simulated hemorrhage in humans. Knowledge gaps in this field of investigation will be presented, and future research directions will be discussed.
KW - Cerebral blood flow
KW - Impedance threshold device
KW - Inspiratory resistance breathing
KW - Intracranial pressure
UR - http://www.scopus.com/inward/record.url?scp=85056872354&partnerID=8YFLogxK
U2 - 10.1016/j.resp.2018.10.001
DO - 10.1016/j.resp.2018.10.001
M3 - Review article
C2 - 30340016
AN - SCOPUS:85056872354
SN - 1569-9048
VL - 265
SP - 76
EP - 82
JO - Respiratory Physiology and Neurobiology
JF - Respiratory Physiology and Neurobiology
ER -