Verteporfin-loaded anisotropic poly(Beta-amino ester)-based micelles demonstrate brain cancer-selective cytotoxicity and enhanced pharmacokinetics

Engineering & Materials Science

• Micelles 83%
• Cytotoxicity 82%
• Pharmacokinetics 78%
• Esters 60%
• Brain 45%
• Polyethylene glycols 25%
• Tumors 25%
• Astrocytes 17%
• Cells 14%
• Heterografts 9%
• Medical nanotechnology 8%
• Drug delivery 6%
• Hydrophobicity 6%
• Hemodynamics 6%
• Copolymers 5%
• Tissue 4%

Medicine & Life Sciences

• poly(beta-amino ester) 100%
• Verteporfin 81%
• Micelles 66%
• Brain Neoplasms 51%
• Pharmacokinetics 41%
• Glioblastoma 19%
• Astrocytes 9%
• Neoplasms 6%
• Nanomedicine 6%
• Ethylene Glycol 6%
• Blood Circulation 5%
• Hydrophobic and Hydrophilic Interactions 5%
• Drug Liberation 4%
• Heterografts 4%
• Half-Life 4%
• Therapeutics 3%
• Safety 2%
• Brain 2%
• In Vitro Techniques 2%
• Pharmaceutical Preparations 2%

Chemical Compounds

• Verteporfin 46%
• Micelle 43%
• Pharmacokinetics 41%
• Ester 33%
• Drug 6%
• Reaction Half Life 5%
• Safety 5%
• Hydrophobicity 5%
• Poly(ethylene Glycol) 4%
• Copolymer 4%
• Shape 4%