VEGF and ALS: The luckiest growth factor?

David A. Greenberg, Kunlin Jin

Research output: Contribution to journalShort survey

31 Scopus citations

Abstract

Converging evidence points to a role for vascular endothelial growth factor (VEGF) in neuronal protection from hypoxic, ischemic and related forms of injury. Recent findings also suggest a previously unsuspected connection between VEGF and amyotrophic lateral sclerosis (ALS), a major neurodegenerative disease of unknown etiology. Further investigation of the relationship between VEGF and ALS could provide insight into the pathogenesis of ALS, and facilitate the development of therapeutic approaches for this currently untreatable and fatal crippling disease of motor neurons.

Original languageEnglish
Pages (from-to)1-3
Number of pages3
JournalTrends in Molecular Medicine
Volume10
Issue number1
DOIs
StatePublished - Jan 2004

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