Vasodilator function is impaired in burn injury survivors

Steven Anthony Romero, Gilbert Moralez, Manall F. Jaffery, Mu Huang, Craig G. Crandall

Research output: Contribution to journalArticleResearchpeer-review

Abstract

The effect of severe burn injury on vascular health is unknown. We tested the hypothesis that, compared with nonburn control subjects, vasodilator function would be reduced and that pulse-wave velocity (a measure of arterial stiffness) would be increased in individuals with prior burn injuries, the extent of which would be associated with the magnitude of body surface area having sustained a severe burn. Pulse-wave velocity and macrovascular (flow-mediated dilation) and microvascular (reactive hyperemia) dilator functions were assessed in 14 nonburned control subjects and 32 age-matched subjects with well-healed burn injuries. Fifteen subjects with burn injuries covering 17–40% of body surface area were assigned to a moderate burn injury group, and 17 subjects with burn injuries covering <40% of body surface area were assigned to a high burn injury group. Pulse-wave velocity [P < 0.3 (central) and P < 0.3 (peripheral)] did not differ between the three groups. Macrovascular dilator function was reduced in the moderate (P < 0.07) and high (P < 0.05) burn injury groups compared with the control group. Likewise, peak vascular conductance during postocclusive reactive hyperemia differed from the moderate burn injury group (P < 0.08 vs. control) and the high burn injury group (P < 0.05 vs. control). These data suggest that vasodilator function is impaired in well-healed burn injury survivors, with the extent of impairment not dependent on the magnitude of body surface area having sustained a severe burn injury.

Original languageEnglish
Pages (from-to)R1054-R1060
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume315
Issue number5
DOIs
StatePublished - 27 Nov 2018

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Vasodilator Agents
Wounds and Injuries
Body Surface Area
Pulse Wave Analysis
Hyperemia
Vascular Stiffness
Vascular System Injuries
Blood Vessels
Dilatation
Control Groups
Health

Keywords

  • Burn injury
  • Flow-mediated dilation
  • Reactive hyperemia

Cite this

Romero, Steven Anthony ; Moralez, Gilbert ; Jaffery, Manall F. ; Huang, Mu ; Crandall, Craig G. / Vasodilator function is impaired in burn injury survivors. In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 2018 ; Vol. 315, No. 5. pp. R1054-R1060.
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Vasodilator function is impaired in burn injury survivors. / Romero, Steven Anthony; Moralez, Gilbert; Jaffery, Manall F.; Huang, Mu; Crandall, Craig G.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 315, No. 5, 27.11.2018, p. R1054-R1060.

Research output: Contribution to journalArticleResearchpeer-review

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