TY - JOUR
T1 - Vascular risk profile and white matter hyperintensity volume among Mexican Americans and non-Hispanic Whites
T2 - The HABLE study
AU - for the HABLE Study Team
AU - King, Kevin S.
AU - Vintimilla, Raul M.
AU - Braskie, Meredith N.
AU - Wei, Ke
AU - Hall, James R.
AU - Borzage, Matt
AU - Johnson, Leigh A.
AU - Yaffe, Kristine
AU - Toga, Arthur W.
AU - O'Bryant, Sid E.
N1 - Funding Information:
The HABLE study is financially supported by the National Institute on Aging (NIA) (grant R01AG054073).
Publisher Copyright:
© 2022 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association.
PY - 2022
Y1 - 2022
N2 - Introduction: Among vascular risk factors we hypothesized that an increased prevalence of diabetes in Hispanics would be associated with greater white matter hyperintensity (WMH) volume, which may contribute to cognitive decline. Methods: A total of 1318 participants (60% female; 49% Hispanic, 51% non-Hispanic White; age 66.2 ± 8.9 years) underwent clinical evaluation and brain magnetic resonance imaging (MRI). WMH volume associations were assessed with age, sex, and ethnicity and then with vascular risk factors in a selective regression model. Results: WMH volume was greater with older age (P <.0001), Hispanic ethnicity (P =.02), and female sex (P =.049). WMH volume was best predicted by age, diastolic blood pressure, hypertension history, hemoglobin A1c (HbA1c), white blood cell count, and hematocrit (P <.01 for all). Elevated HbA1c was associated with greater WMH volume among Hispanics (parameter estimate 0.08 ± 0.02, P <.0001) but not non-Hispanic Whites (parameter estimate 0.02 ± 0.04, P =.5). Discussion: WMH volume was greater in Hispanics, which may be partly explained by increased WMH volume related to elevated HbA1c among Hispanics but not non-Hispanic Whites.
AB - Introduction: Among vascular risk factors we hypothesized that an increased prevalence of diabetes in Hispanics would be associated with greater white matter hyperintensity (WMH) volume, which may contribute to cognitive decline. Methods: A total of 1318 participants (60% female; 49% Hispanic, 51% non-Hispanic White; age 66.2 ± 8.9 years) underwent clinical evaluation and brain magnetic resonance imaging (MRI). WMH volume associations were assessed with age, sex, and ethnicity and then with vascular risk factors in a selective regression model. Results: WMH volume was greater with older age (P <.0001), Hispanic ethnicity (P =.02), and female sex (P =.049). WMH volume was best predicted by age, diastolic blood pressure, hypertension history, hemoglobin A1c (HbA1c), white blood cell count, and hematocrit (P <.01 for all). Elevated HbA1c was associated with greater WMH volume among Hispanics (parameter estimate 0.08 ± 0.02, P <.0001) but not non-Hispanic Whites (parameter estimate 0.02 ± 0.04, P =.5). Discussion: WMH volume was greater in Hispanics, which may be partly explained by increased WMH volume related to elevated HbA1c among Hispanics but not non-Hispanic Whites.
KW - Hispanic
KW - cerebral microvascular disease
KW - diabetes
KW - leukoaraiosis
KW - white matter hyperintensity
UR - http://www.scopus.com/inward/record.url?scp=85133551352&partnerID=8YFLogxK
U2 - 10.1002/dad2.12263
DO - 10.1002/dad2.12263
M3 - Article
AN - SCOPUS:85133551352
SN - 2352-8729
VL - 14
JO - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
JF - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
IS - 1
M1 - e12263
ER -