Vascular endothelial growth factors (VEGFs) and stroke

David A. Greenberg, Kunlin Jin

Research output: Contribution to journalReview article

143 Scopus citations

Abstract

Vascular endothelial growth factors (VEGFs) have been shown to participate in atherosclerosis, arteriogenesis, cerebral edema, neuroprotection, neurogenesis, angiogenesis, postischemic brain and vessel repair, and the effects of transplanted stem cells in experimental stroke. Most of these actions involve VEGF-A and the VEGFR-2 receptor, but VEGF-B, placental growth factor, and VEGFR-1 have been implicated in some cases as well. VEGF signaling pathways represent important potential targets for the acute and chronic treatment of stroke.

Original languageEnglish
Pages (from-to)1753-1761
Number of pages9
JournalCellular and Molecular Life Sciences
Volume70
Issue number10
DOIs
StatePublished - 2013

Keywords

  • Angiogenesis
  • Ischemia
  • Neurogenesis
  • Neuroprotection
  • Stroke
  • Vascular endothelial growth factor

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