Vascular endothelial growth factors (VEGFs) and stroke

David A. Greenberg; Kunlin Jin

doi:10.1007/s00018-013-1282-8

Vascular endothelial growth factors (VEGFs) and stroke

David A. Greenberg, Kunlin Jin

Research output: Contribution to journal › Review article › peer-review

195 Scopus citations

Abstract

Vascular endothelial growth factors (VEGFs) have been shown to participate in atherosclerosis, arteriogenesis, cerebral edema, neuroprotection, neurogenesis, angiogenesis, postischemic brain and vessel repair, and the effects of transplanted stem cells in experimental stroke. Most of these actions involve VEGF-A and the VEGFR-2 receptor, but VEGF-B, placental growth factor, and VEGFR-1 have been implicated in some cases as well. VEGF signaling pathways represent important potential targets for the acute and chronic treatment of stroke.

Original language	English
Pages (from-to)	1753-1761
Number of pages	9
Journal	Cellular and Molecular Life Sciences
Volume	70
Issue number	10
DOIs	https://doi.org/10.1007/s00018-013-1282-8
State	Published - May 2013

Keywords

Angiogenesis
Ischemia
Neurogenesis
Neuroprotection
Stroke
Vascular endothelial growth factor

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10.1007/s00018-013-1282-8

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title = "Vascular endothelial growth factors (VEGFs) and stroke",

abstract = "Vascular endothelial growth factors (VEGFs) have been shown to participate in atherosclerosis, arteriogenesis, cerebral edema, neuroprotection, neurogenesis, angiogenesis, postischemic brain and vessel repair, and the effects of transplanted stem cells in experimental stroke. Most of these actions involve VEGF-A and the VEGFR-2 receptor, but VEGF-B, placental growth factor, and VEGFR-1 have been implicated in some cases as well. VEGF signaling pathways represent important potential targets for the acute and chronic treatment of stroke.",

keywords = "Angiogenesis, Ischemia, Neurogenesis, Neuroprotection, Stroke, Vascular endothelial growth factor",

author = "Greenberg, {David A.} and Kunlin Jin",

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AU - Greenberg, David A.

AU - Jin, Kunlin

N1 - Funding Information: This study was supported by National Institutes of Health grant R01 NS44921.

PY - 2013/5

Y1 - 2013/5

N2 - Vascular endothelial growth factors (VEGFs) have been shown to participate in atherosclerosis, arteriogenesis, cerebral edema, neuroprotection, neurogenesis, angiogenesis, postischemic brain and vessel repair, and the effects of transplanted stem cells in experimental stroke. Most of these actions involve VEGF-A and the VEGFR-2 receptor, but VEGF-B, placental growth factor, and VEGFR-1 have been implicated in some cases as well. VEGF signaling pathways represent important potential targets for the acute and chronic treatment of stroke.

AB - Vascular endothelial growth factors (VEGFs) have been shown to participate in atherosclerosis, arteriogenesis, cerebral edema, neuroprotection, neurogenesis, angiogenesis, postischemic brain and vessel repair, and the effects of transplanted stem cells in experimental stroke. Most of these actions involve VEGF-A and the VEGFR-2 receptor, but VEGF-B, placental growth factor, and VEGFR-1 have been implicated in some cases as well. VEGF signaling pathways represent important potential targets for the acute and chronic treatment of stroke.

KW - Angiogenesis

KW - Ischemia

KW - Neurogenesis

KW - Neuroprotection

KW - Stroke

KW - Vascular endothelial growth factor

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U2 - 10.1007/s00018-013-1282-8

DO - 10.1007/s00018-013-1282-8

M3 - Review article

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AN - SCOPUS:84876923460

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SP - 1753

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JO - Cellular and Molecular Life Sciences

JF - Cellular and Molecular Life Sciences

IS - 10

ER -

Vascular endothelial growth factors (VEGFs) and stroke

Abstract

Keywords

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