Abstract
Vascular endothelial growth factors (VEGFs) have been shown to participate in atherosclerosis, arteriogenesis, cerebral edema, neuroprotection, neurogenesis, angiogenesis, postischemic brain and vessel repair, and the effects of transplanted stem cells in experimental stroke. Most of these actions involve VEGF-A and the VEGFR-2 receptor, but VEGF-B, placental growth factor, and VEGFR-1 have been implicated in some cases as well. VEGF signaling pathways represent important potential targets for the acute and chronic treatment of stroke.
Original language | English |
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Pages (from-to) | 1753-1761 |
Number of pages | 9 |
Journal | Cellular and Molecular Life Sciences |
Volume | 70 |
Issue number | 10 |
DOIs | |
State | Published - May 2013 |
Keywords
- Angiogenesis
- Ischemia
- Neurogenesis
- Neuroprotection
- Stroke
- Vascular endothelial growth factor