Vascular endothelial growth factors (VEGFs) and stroke

David A. Greenberg, Kunlin Jin

Research output: Contribution to journalReview article

119 Citations (Scopus)

Abstract

Vascular endothelial growth factors (VEGFs) have been shown to participate in atherosclerosis, arteriogenesis, cerebral edema, neuroprotection, neurogenesis, angiogenesis, postischemic brain and vessel repair, and the effects of transplanted stem cells in experimental stroke. Most of these actions involve VEGF-A and the VEGFR-2 receptor, but VEGF-B, placental growth factor, and VEGFR-1 have been implicated in some cases as well. VEGF signaling pathways represent important potential targets for the acute and chronic treatment of stroke.

Original languageEnglish
Pages (from-to)1753-1761
Number of pages9
JournalCellular and Molecular Life Sciences
Volume70
Issue number10
DOIs
StatePublished - 11 Mar 2013

Fingerprint

Vascular Endothelial Growth Factors
Vascular Endothelial Growth Factor B
Stroke
Vascular Endothelial Growth Factor Receptor-1
Vascular Endothelial Growth Factor Receptor-2
Neurogenesis
Brain Edema
Vascular Endothelial Growth Factor A
Atherosclerosis
Intercellular Signaling Peptides and Proteins
Stem Cells
Brain

Keywords

  • Angiogenesis
  • Ischemia
  • Neurogenesis
  • Neuroprotection
  • Stroke
  • Vascular endothelial growth factor

Cite this

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Vascular endothelial growth factors (VEGFs) and stroke. / Greenberg, David A.; Jin, Kunlin.

In: Cellular and Molecular Life Sciences, Vol. 70, No. 10, 11.03.2013, p. 1753-1761.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Vascular endothelial growth factors (VEGFs) and stroke

AU - Greenberg, David A.

AU - Jin, Kunlin

PY - 2013/3/11

Y1 - 2013/3/11

N2 - Vascular endothelial growth factors (VEGFs) have been shown to participate in atherosclerosis, arteriogenesis, cerebral edema, neuroprotection, neurogenesis, angiogenesis, postischemic brain and vessel repair, and the effects of transplanted stem cells in experimental stroke. Most of these actions involve VEGF-A and the VEGFR-2 receptor, but VEGF-B, placental growth factor, and VEGFR-1 have been implicated in some cases as well. VEGF signaling pathways represent important potential targets for the acute and chronic treatment of stroke.

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KW - Ischemia

KW - Neurogenesis

KW - Neuroprotection

KW - Stroke

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U2 - 10.1007/s00018-013-1282-8

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