Vascular endothelial growth factor overexpression delays neurodegeneration and prolongs survival in amyotrophic lateral sclerosis mice

Yaoming Wang, Ou Mao Xiao, Lin Xie, Surita Banwait, Hugo H. Marti, David A. Greenberg, Kunlin Jin

Research output: Contribution to journalArticle

137 Scopus citations

Abstract

We sought genetic evidence for the involvement of neuronal vascular endothelial growth factor (VEGF) in amyotrophic lateral sclerosis (ALS). Mice expressing human ALS mutant superoxide dismutase-1 (SOD1) were crossed with mice that overexpress VEGF in neurons (VEGF+/+). We report that SOD1G93A/VEGF+/+ double-transgenic mice show delayed motor neuron loss, delayed motor impairment, and prolonged survival compared with SOD1G93A single transgenics. These findings indicate that neuronal VEGF protects against motor neuron degeneration, and may have therapeutic implications for ALS.

Original languageEnglish
Pages (from-to)304-307
Number of pages4
JournalJournal of Neuroscience
Volume27
Issue number2
DOIs
StatePublished - 10 Jan 2007

Keywords

  • Amyotrophic lateral sclerosis
  • Motor neuron
  • Neurodegeneration
  • Superoxide dismutase-1
  • Transgenic
  • Vascular endothelial growth factor

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