Abstract
Background: Vascular endothelial growth factor-B (VEGF-B) protects against experimental stroke, but the effect of stroke on VEGF-B expression is uncertain. Methods. We examined VEGF-B expression by immunohistochemistry in the ischemic border zone 1-7 days after middle cerebral artery occlusion in rats. Results: VEGF-B immunoreactivity in the border zone was increased after middle cerebral artery occlusion and was associated with neurons and macrophages/microglia, but not astrocytes or endothelial cells. Conclusions: These findings provide additional evidence for a role of VEGF-B in the endogenous response to cerebral ischemia.
Original language | English |
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Article number | 8 |
Journal | Vascular Cell |
Volume | 5 |
Issue number | 1 |
DOIs | |
State | Published - 2013 |
Keywords
- Ischemia
- Stroke
- Vascular endothelial growth factor-B (VEGF-B)