Vascular endothelial growth factor-B expression in postischemic rat brain

Lin Xie, Xiaoou Mao, Kunlin Jin, David A. Greenberg

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Background: Vascular endothelial growth factor-B (VEGF-B) protects against experimental stroke, but the effect of stroke on VEGF-B expression is uncertain. Methods. We examined VEGF-B expression by immunohistochemistry in the ischemic border zone 1-7 days after middle cerebral artery occlusion in rats. Results: VEGF-B immunoreactivity in the border zone was increased after middle cerebral artery occlusion and was associated with neurons and macrophages/microglia, but not astrocytes or endothelial cells. Conclusions: These findings provide additional evidence for a role of VEGF-B in the endogenous response to cerebral ischemia.

Original languageEnglish
Article number8
JournalVascular Cell
Volume5
Issue number1
DOIs
StatePublished - 2013

Keywords

  • Ischemia
  • Stroke
  • Vascular endothelial growth factor-B (VEGF-B)

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