Vascular Endothelial Cell Dysfunction in Preeclampsia

Styliani Goulopoulou, Christianne De Groot, Robert N. Taylor, Sandra T. Davidge

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


In the early 1980s, physicians and scientists began to gain an appreciation of the physiological importance of the endothelium, the simple unicellular layer lining the luminal surface of blood vessels. Indeed, in Chesley’s first, single-authored edition of this text, the reference to this term was confined to the “endotheliosis” lesion of the renal glomerulus. We now recognize that endothelial cells are critical sensors of the milieu interieur and potent regulators of vascular tone, organ perfusion, and ischemia. The “endothelial hypothesis” of preeclampsia etiology provides for a convergence of several factors thought to play fundamental roles in its pathogenesis: leukocytes, platelets, cytokines, fatty acids, oxygen free radicals, placental microvesicles, cell-free DNA fragments, “antiangiogenic” factors, and autoantibodies are all considered.

Original languageEnglish
Title of host publicationChesley’s Hypertensive Disorders in Pregnancy
Number of pages32
ISBN (Electronic)9780128184172
ISBN (Print)9780128184189
StatePublished - 1 Jan 2021


  • Cyclooxygenase
  • Mitochondria
  • NEFA (nonesterified fatty acids)
  • Neutrophils
  • Nitric oxide
  • Xanthine oxidase


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