Variant Translocations of Chromosome 13 in Alveolar Rhabdomyosarcoma

Edwin C. Douglass; Susan T. Rowe; Marc Valentine; David M. Parham; Roger Berkow; W. Paul Bowman; Harold M. Maurer

doi:10.1002/gcc.2870030611

Variant Translocations of Chromosome 13 in Alveolar Rhabdomyosarcoma

Edwin C. Douglass, Susan T. Rowe, Marc Valentine, David M. Parham, Roger Berkow, W. Paul Bowman, Harold M. Maurer

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Abstract

In three cases of alveolar rhabdomyosarcoma with variant translocations, two tumors contained an identical translocation, t(1;13)(p36.1;q14); the third tumor contained a t(8;13)(p21;q14). All three patients were 2 years old, markedly younger than the median age for patients with t(2; 13)‐positive alveolar rhabdomyosarcoma. The alteration of genetic material on chromosome 13 may be of primary importance in the development of alveolar rhabdomyosarcoma.

Original language	English
Pages (from-to)	480-482
Number of pages	3
Journal	Genes, Chromosomes and Cancer
Volume	3
Issue number	6
DOIs	https://doi.org/10.1002/gcc.2870030611
State	Published - Nov 1991

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abstract = "In three cases of alveolar rhabdomyosarcoma with variant translocations, two tumors contained an identical translocation, t(1;13)(p36.1;q14); the third tumor contained a t(8;13)(p21;q14). All three patients were 2 years old, markedly younger than the median age for patients with t(2; 13)‐positive alveolar rhabdomyosarcoma. The alteration of genetic material on chromosome 13 may be of primary importance in the development of alveolar rhabdomyosarcoma.",

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AU - Rowe, Susan T.

AU - Valentine, Marc

AU - Parham, David M.

AU - Berkow, Roger

AU - Paul Bowman, W.

AU - Maurer, Harold M.

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AB - In three cases of alveolar rhabdomyosarcoma with variant translocations, two tumors contained an identical translocation, t(1;13)(p36.1;q14); the third tumor contained a t(8;13)(p21;q14). All three patients were 2 years old, markedly younger than the median age for patients with t(2; 13)‐positive alveolar rhabdomyosarcoma. The alteration of genetic material on chromosome 13 may be of primary importance in the development of alveolar rhabdomyosarcoma.

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ER -

Variant Translocations of Chromosome 13 in Alveolar Rhabdomyosarcoma

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