TY - JOUR
T1 - Valsalva's maneuver revisited
T2 - A quantitative method yielding insights into human autonomic control
AU - Smith, Michael L.
AU - Beightol, Larry A.
AU - Fritsch-Yelle, Janice M.
AU - Ellenbogen, Kenneth A.
AU - Porter, Thomas R.
AU - Eckberg, Dwain L.
PY - 1996/9
Y1 - 1996/9
N2 - Seventeen healthy supine subjects, performed graded Valsalva maneuvers. In four objects, transesophageal echographic aortic cross-sectional area decreased during and after straining. During the first seconds of straining, when aortic cross-sectional areas was declining and peripheral arterial pressure was rising, peroneal sympathetic muscle neurons were nearly silent. Then, as aortic cross-sectional area and peripheral pressure both declined, sympathetic muscle nerve activity increase, in proportion to the intensity of straining. Poststraining arterial pressure elevations were proportional to preceding increases of sympathetic activity. Sympathetic inhibition after staining persisted must longer than arterial and right atrial pressure elevations. Similarly, R-R intervals ~45 s after the onset of straining, when R-R intervals were greater and arterial pressures were smaller than prestraining levels. Our conclusions are as follows: opposing changes of carotid and aortic baroreceptor inputs reduce sympathetic muscle and increase vagal cardiac motor neuronal firing; parallel changes of barosensory inputs provoke reciprocal changes of barosensory inputs provoke reciprocal changes of sympathetic and direct changes of vagal firing; and pressure transients lasting only seconds reset arterial pressure-sympathetic and -vagal response relations.
AB - Seventeen healthy supine subjects, performed graded Valsalva maneuvers. In four objects, transesophageal echographic aortic cross-sectional area decreased during and after straining. During the first seconds of straining, when aortic cross-sectional areas was declining and peripheral arterial pressure was rising, peroneal sympathetic muscle neurons were nearly silent. Then, as aortic cross-sectional area and peripheral pressure both declined, sympathetic muscle nerve activity increase, in proportion to the intensity of straining. Poststraining arterial pressure elevations were proportional to preceding increases of sympathetic activity. Sympathetic inhibition after staining persisted must longer than arterial and right atrial pressure elevations. Similarly, R-R intervals ~45 s after the onset of straining, when R-R intervals were greater and arterial pressures were smaller than prestraining levels. Our conclusions are as follows: opposing changes of carotid and aortic baroreceptor inputs reduce sympathetic muscle and increase vagal cardiac motor neuronal firing; parallel changes of barosensory inputs provoke reciprocal changes of barosensory inputs provoke reciprocal changes of sympathetic and direct changes of vagal firing; and pressure transients lasting only seconds reset arterial pressure-sympathetic and -vagal response relations.
KW - arterial pressure
KW - baroreceptors
KW - baroreflex resetting
KW - microneurography
KW - sympathetic
KW - vagal
UR - http://www.scopus.com/inward/record.url?scp=33750712103&partnerID=8YFLogxK
U2 - 10.1152/ajpheart.1996.271.3.h1240
DO - 10.1152/ajpheart.1996.271.3.h1240
M3 - Article
C2 - 8853364
AN - SCOPUS:33750712103
SN - 0363-6135
VL - 271
SP - H1240-H1249
JO - American Journal of Physiology - Heart and Circulatory Physiology
JF - American Journal of Physiology - Heart and Circulatory Physiology
IS - 3 40-3
ER -