TY - JOUR
T1 - Utility of the affected sib pair method to detect linkage of a sex‐linked dominant disease with a sex‐linked recessive trait
AU - Chakraborty, Ranajit
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1989
Y1 - 1989
N2 - Use of affected sib‐pairs for linkage determination of a sex‐linked dominant disease with a recessive X‐chromosome marker will require extremely large sample sizes, particularly when the marker is marginally polymorphic. In addition, this method should not be used without caution on data collected for a traditional LOD score analysis, without considering the parental mating types involved in the informative families. Nevertheless, ascertainment adjustment and correction for dependence of multiple pairs of affected sib‐pairs in families suggests that this method provides linkage inference concordant with that of the traditional LOD score analysis.
AB - Use of affected sib‐pairs for linkage determination of a sex‐linked dominant disease with a recessive X‐chromosome marker will require extremely large sample sizes, particularly when the marker is marginally polymorphic. In addition, this method should not be used without caution on data collected for a traditional LOD score analysis, without considering the parental mating types involved in the informative families. Nevertheless, ascertainment adjustment and correction for dependence of multiple pairs of affected sib‐pairs in families suggests that this method provides linkage inference concordant with that of the traditional LOD score analysis.
KW - X‐linked dominant disease
KW - color blindness
KW - sample size requirement
UR - http://www.scopus.com/inward/record.url?scp=0024487892&partnerID=8YFLogxK
U2 - 10.1002/gepi.1370060149
DO - 10.1002/gepi.1370060149
M3 - Article
C2 - 2786486
AN - SCOPUS:0024487892
SN - 0741-0395
VL - 6
SP - 281
EP - 286
JO - Genetic Epidemiology
JF - Genetic Epidemiology
IS - 1
ER -