Utility of Physiologically Based Pharmacokinetic Modeling in Point-of-Care Decisions: An Example Using Digoxin Dosing in Continuous Venovenous Hemodiafiltration

Meenakshi Srinivasan, Raiz Hirani, Melissa Tsiu, Khadija Kabani, Ayyappa Chaturvedula, Brittany Palasik

Research output: Contribution to journalArticlepeer-review

Abstract

We describe the case of a patient on continuous venovenous hemodiafiltration with atrial fibrillation with rapid ventricular response and hypotension requiring vasopressor use, which warranted digoxin therapy. In the absence of guidelines specifying appropriate digoxin dosing in patients undergoing continuous venovenous hemodiafiltration, anecdotal evidence-guided digoxin dosing was performed for this patient using plasma digoxin concentration-based therapeutic drug monitoring. We use this case to demonstrate the potential role of physiologically based pharmacokinetic modeling in assisting therapeutic decision making.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalTherapeutic drug monitoring
Volume42
Issue number1
DOIs
StatePublished - 1 Feb 2020

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