TY - JOUR
T1 - Utility of Physiologically Based Pharmacokinetic Modeling in Point-of-Care Decisions
T2 - An Example Using Digoxin Dosing in Continuous Venovenous Hemodiafiltration
AU - Srinivasan, Meenakshi
AU - Hirani, Raiz
AU - Tsiu, Melissa
AU - Kabani, Khadija
AU - Chaturvedula, Ayyappa
AU - Palasik, Brittany
PY - 2020/2/1
Y1 - 2020/2/1
N2 - We describe the case of a patient on continuous venovenous hemodiafiltration with atrial fibrillation with rapid ventricular response and hypotension requiring vasopressor use, which warranted digoxin therapy. In the absence of guidelines specifying appropriate digoxin dosing in patients undergoing continuous venovenous hemodiafiltration, anecdotal evidence-guided digoxin dosing was performed for this patient using plasma digoxin concentration-based therapeutic drug monitoring. We use this case to demonstrate the potential role of physiologically based pharmacokinetic modeling in assisting therapeutic decision making.
AB - We describe the case of a patient on continuous venovenous hemodiafiltration with atrial fibrillation with rapid ventricular response and hypotension requiring vasopressor use, which warranted digoxin therapy. In the absence of guidelines specifying appropriate digoxin dosing in patients undergoing continuous venovenous hemodiafiltration, anecdotal evidence-guided digoxin dosing was performed for this patient using plasma digoxin concentration-based therapeutic drug monitoring. We use this case to demonstrate the potential role of physiologically based pharmacokinetic modeling in assisting therapeutic decision making.
UR - http://www.scopus.com/inward/record.url?scp=85077761070&partnerID=8YFLogxK
U2 - 10.1097/FTD.0000000000000704
DO - 10.1097/FTD.0000000000000704
M3 - Article
C2 - 31593032
AN - SCOPUS:85077761070
SN - 0163-4356
VL - 42
SP - 1
EP - 5
JO - Therapeutic Drug Monitoring
JF - Therapeutic Drug Monitoring
IS - 1
ER -