Universal inactivation of both p16 and p15 but not downstream components is an essential event in the pathogenesis of T-cell acute lymphoblastic leukemia

Keyphrases

• Abrogation 16%
• Cell Cycle Pathway 33%
• Cyclin 50%
• Cyclin-dependent Kinase 4 (CDK4) 50%
• Deletion mutation 16%
• Deregulation 16%
• Hypermethylation 16%
• MRNA Level 33%
• P15 Gene 50%
• P15 Protein 16%
• P16 Expression 16%
• P16 Gene 16%
• P16 Protein 16%
• Phosphorylation 16%
• Protein Level 50%
• Regulatory Pathways 16%
• RNA-protein Complex 16%
• T-cell Acute Lymphoblastic Leukemia (T-ALL) 100%

Biochemistry, Genetics and Molecular Biology

• Cell Cycle 30%
• Cyclin 30%
• DNA RNA Hybridization 10%
• Messenger RNA 10%
• P16 100%
• Proliferating Cell Nuclear Antigen 30%
• RNA 20%
• T Cell 100%
• Wild Type 20%