TY - JOUR
T1 - Understanding the Interplay Between Health Disparities and Epigenomics
AU - Mancilla, Viviana J.
AU - Peeri, Noah C.
AU - Silzer, Talisa
AU - Basha, Riyaz
AU - Felini, Martha
AU - Jones, Harlan P.
AU - Phillips, Nicole
AU - Tao, Meng Hua
AU - Thyagarajan, Srikantha
AU - Vishwanatha, Jamboor K.
N1 - Funding Information:
The funding for the conference on which this review is based was made possible by the National Institute on Minority Health and Health Disparities of the National Institutes of Health under Award Numbers U54MD006882 and S21MD012472. The views presented in the written review were presented by speakers and moderators and do not reflect the official policies of the Department of Health and Human Services, nor does mention of trade names, commercial practices, or organizations imply endorsement by the United States Government. The authors would like to thank the speakers of the 14th Annual Texas Conference on Health Disparities for presenting the information on their research. The authors also thank all the community organization members who took part in the conference. Funding. This research reported in this publication was supported by the National Institute on Minority Health and Health Disparities of the National Institutes of Health under Award Numbers U54MD006882 and S21MD012472.
Publisher Copyright:
© Copyright © 2020 Mancilla, Peeri, Silzer, Basha, Felini, Jones, Phillips, Tao, Thyagarajan and Vishwanatha.
PY - 2020/8/20
Y1 - 2020/8/20
N2 - Social epigenomics has emerged as an integrative field of research focused on identification of socio-environmental factors, their influence on human biology through epigenomic modifications, and how they contribute to current health disparities. Several health disparities studies have been published using genetic-based approaches; however, increasing accessibility and affordability of molecular technologies have allowed for an in-depth investigation of the influence of external factors on epigenetic modifications (e.g., DNA methylation, micro-RNA expression). Currently, research is focused on epigenetic changes in response to environment, as well as targeted epigenetic therapies and environmental/social strategies for potentially minimizing certain health disparities. Here, we will review recent findings in this field pertaining to conditions and diseases over life span encompassing prenatal to adult stages.
AB - Social epigenomics has emerged as an integrative field of research focused on identification of socio-environmental factors, their influence on human biology through epigenomic modifications, and how they contribute to current health disparities. Several health disparities studies have been published using genetic-based approaches; however, increasing accessibility and affordability of molecular technologies have allowed for an in-depth investigation of the influence of external factors on epigenetic modifications (e.g., DNA methylation, micro-RNA expression). Currently, research is focused on epigenetic changes in response to environment, as well as targeted epigenetic therapies and environmental/social strategies for potentially minimizing certain health disparities. Here, we will review recent findings in this field pertaining to conditions and diseases over life span encompassing prenatal to adult stages.
KW - cancer
KW - chronic disease
KW - epigenetics
KW - health disparities
KW - social determinants of health
UR - http://www.scopus.com/inward/record.url?scp=85090267853&partnerID=8YFLogxK
U2 - 10.3389/fgene.2020.00903
DO - 10.3389/fgene.2020.00903
M3 - Review article
AN - SCOPUS:85090267853
SN - 1664-8021
VL - 11
JO - Frontiers in Genetics
JF - Frontiers in Genetics
M1 - 903
ER -