Understanding the Interplay Between Health Disparities and Epigenomics

Viviana J. Mancilla, Noah C. Peeri, Talisa Silzer, Riyaz Basha, Martha Felini, Harlan P. Jones, Nicole Phillips, Meng Hua Tao, Srikantha Thyagarajan, Jamboor K. Vishwanatha

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Social epigenomics has emerged as an integrative field of research focused on identification of socio-environmental factors, their influence on human biology through epigenomic modifications, and how they contribute to current health disparities. Several health disparities studies have been published using genetic-based approaches; however, increasing accessibility and affordability of molecular technologies have allowed for an in-depth investigation of the influence of external factors on epigenetic modifications (e.g., DNA methylation, micro-RNA expression). Currently, research is focused on epigenetic changes in response to environment, as well as targeted epigenetic therapies and environmental/social strategies for potentially minimizing certain health disparities. Here, we will review recent findings in this field pertaining to conditions and diseases over life span encompassing prenatal to adult stages.

Original languageEnglish
Article number903
JournalFrontiers in Genetics
Volume11
DOIs
StatePublished - 20 Aug 2020

Keywords

  • cancer
  • chronic disease
  • epigenetics
  • health disparities
  • social determinants of health

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