Ubiquitous nonimmunoglobulin p-azobenzenearsonate-binding molecules from lymphoid cells

Abbot Clark, J. D. Capra

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

A ubiquitous nonimmunglobulin molecule that binds p-azobenzenearsonate (ABA) has been detected in the cytoplasm of several murine cell lines, including T cell hybridomas as well as in normal liver and spleen. Similar to many recently described antigen-specific T cell factors, this ABA-binding protein has a 62,000 mol wt, and, when analyzed by direct binding, the molecule reacts with several different rabbit anti-idiotypic antisera specific to the ABA system. The presence of this antigenspecific, 'idiotype positive' molecule in many different cells indicates that it is not an important immunoregulatory molecule.

Original languageEnglish
Pages (from-to)611-616
Number of pages6
JournalJournal of Experimental Medicine
Volume155
Issue number2
DOIs
StatePublished - 1 Jan 1982

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p-Azobenzenearsonate
Lymphocytes
Hybridomas
Immune Sera
Carrier Proteins
Cytoplasm
Spleen
Rabbits
T-Lymphocytes
Cell Line
Liver

Cite this

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abstract = "A ubiquitous nonimmunglobulin molecule that binds p-azobenzenearsonate (ABA) has been detected in the cytoplasm of several murine cell lines, including T cell hybridomas as well as in normal liver and spleen. Similar to many recently described antigen-specific T cell factors, this ABA-binding protein has a 62,000 mol wt, and, when analyzed by direct binding, the molecule reacts with several different rabbit anti-idiotypic antisera specific to the ABA system. The presence of this antigenspecific, 'idiotype positive' molecule in many different cells indicates that it is not an important immunoregulatory molecule.",
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Ubiquitous nonimmunoglobulin p-azobenzenearsonate-binding molecules from lymphoid cells. / Clark, Abbot; Capra, J. D.

In: Journal of Experimental Medicine, Vol. 155, No. 2, 01.01.1982, p. 611-616.

Research output: Contribution to journalArticle

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