Two faces of protein kinase Cδ

The contrasting roles of PKCδ in cell survival and cell death

Alakananda Basu, Deepanwita Pal

Research output: Contribution to journalReview articleResearchpeer-review

84 Citations (Scopus)

Abstract

Protein kinase Cδ (PKCδ) is a member of the PKC family that plays a critical role in the regulation of various cellular processes, including cell proliferation, cell death, and tumor promotion. Since the identification that PKCδ is a substrate for caspase-3, there has been overwhelming literature that linked PKCδ with proapoptotic signaling. While PKCδ generally functions as a proapoptotic protein during DNA damage-induced apoptosis, it can act as an antiapoptotic protein during receptor-initiated cell death. PKCδ has also been implicated in tumor suppression as well as survival of several cancers. The function of PKCδ depends on various factors, including its localization, tyrosine phosphorylation, and the presence of other pro- and antiapoptoic signaling molecules. This review discusses the current literature on the contrasting roles of PKCδ in cell survival and cell death.

Original languageEnglish
Pages (from-to)2272-2284
Number of pages13
JournalTheScientificWorldJournal
Volume10
DOIs
StatePublished - 16 Nov 2010

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Cell death
Protein Kinase C
Cell Survival
Cell Death
Cells
protein
Tumors
tumor
Neoplasms
Phosphorylation
Cell proliferation
Caspase 3
DNA Damage
Tyrosine
apoptosis
Proteins
literature review
Cell Proliferation
Apoptosis
cancer

Keywords

  • Apoptosis
  • Cell survival
  • DNA damage-induced apoptosis
  • PKCδ
  • Protein kinase C
  • Receptor-mediated apoptosis
  • Signal transduction
  • Tumor promotion
  • Tumor suppression
  • p53

Cite this

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abstract = "Protein kinase Cδ (PKCδ) is a member of the PKC family that plays a critical role in the regulation of various cellular processes, including cell proliferation, cell death, and tumor promotion. Since the identification that PKCδ is a substrate for caspase-3, there has been overwhelming literature that linked PKCδ with proapoptotic signaling. While PKCδ generally functions as a proapoptotic protein during DNA damage-induced apoptosis, it can act as an antiapoptotic protein during receptor-initiated cell death. PKCδ has also been implicated in tumor suppression as well as survival of several cancers. The function of PKCδ depends on various factors, including its localization, tyrosine phosphorylation, and the presence of other pro- and antiapoptoic signaling molecules. This review discusses the current literature on the contrasting roles of PKCδ in cell survival and cell death.",
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Two faces of protein kinase Cδ : The contrasting roles of PKCδ in cell survival and cell death. / Basu, Alakananda; Pal, Deepanwita.

In: TheScientificWorldJournal, Vol. 10, 16.11.2010, p. 2272-2284.

Research output: Contribution to journalReview articleResearchpeer-review

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AU - Pal, Deepanwita

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