Tumor-Targeting NIRF NanoGUMBOS with Cyclodextrin-Enhanced Chemo/Photothermal Antitumor Activities

Mi Chen, Roció L. Pérez, Pu Du, Nimisha Bhattarai, Karen C. McDonough, Sudhir Ravula, Revati Kumar, J. Michael Mathis, Isiah M. Warner

Research output: Contribution to journalArticle

Abstract

The near-infrared fluorescent (NIRF) dye, IR780, is recognized as a promising theranostic agent and has been widely investigated for imaging, chemotherapeutic, and phototherapeutic applications. However, its poor photostability and nonselective toxicities toward both cancer and normal cells limit its biological applications. Herein, we introduce the use of GUMBOS (a group of uniform materials based on organic salts) developed through counter-anion exchange with IR780 and subsequent nanomaterials (nanoGUMBOS) formed by complexation with cyclodextrin (CD) for enhanced chemo/photothermal therapy. Such CD-based nanoGUMBOS display improved aqueous stability, photostability, and photothermal effects relative to traditional IR780. The examination of in vitro cytotoxicity reveals that CD-based nanoGUMBOS are selectively toxic toward cancer cells and exhibit synergistically enhanced cytotoxicity toward cancer cells upon NIR laser irradiation. Additionally, in vivo NIRF imaging demonstrated selective accumulation of these nanoGUMBOS within the tumor site, indicating tumor-targeting properties. Further in vivo therapeutic study of these CD-based nanoGUMBOS suggests excellent chemo/photothermal antitumor effects. Using these studies, we herein demonstrate a promising strategy, via conversion of IR780 into nanoGUMBOS, that can be used for improved theranostic cancer treatment.

Original languageEnglish
Pages (from-to)27548-27557
Number of pages10
JournalACS Applied Materials and Interfaces
Volume11
Issue number31
DOIs
StatePublished - 8 Jul 2019

Fingerprint

Cyclodextrins
Tumors
Infrared radiation
Cytotoxicity
Cells
Imaging techniques
Oncology
Chemotherapy
Poisons
Laser beam effects
Complexation
Fluorescent Dyes
Nanostructured materials
Anions
Toxicity
Ion exchange
Negative ions
Dyes
Salts
Display devices

Keywords

  • IR780
  • NIRF
  • chemo/photothermal applications
  • cyclodextrin
  • nanoGUMBOS
  • theranostic

Cite this

Chen, M., Pérez, R. L., Du, P., Bhattarai, N., McDonough, K. C., Ravula, S., ... Warner, I. M. (2019). Tumor-Targeting NIRF NanoGUMBOS with Cyclodextrin-Enhanced Chemo/Photothermal Antitumor Activities. ACS Applied Materials and Interfaces, 11(31), 27548-27557. https://doi.org/10.1021/acsami.9b08047
Chen, Mi ; Pérez, Roció L. ; Du, Pu ; Bhattarai, Nimisha ; McDonough, Karen C. ; Ravula, Sudhir ; Kumar, Revati ; Mathis, J. Michael ; Warner, Isiah M. / Tumor-Targeting NIRF NanoGUMBOS with Cyclodextrin-Enhanced Chemo/Photothermal Antitumor Activities. In: ACS Applied Materials and Interfaces. 2019 ; Vol. 11, No. 31. pp. 27548-27557.
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Chen, M, Pérez, RL, Du, P, Bhattarai, N, McDonough, KC, Ravula, S, Kumar, R, Mathis, JM & Warner, IM 2019, 'Tumor-Targeting NIRF NanoGUMBOS with Cyclodextrin-Enhanced Chemo/Photothermal Antitumor Activities', ACS Applied Materials and Interfaces, vol. 11, no. 31, pp. 27548-27557. https://doi.org/10.1021/acsami.9b08047

Tumor-Targeting NIRF NanoGUMBOS with Cyclodextrin-Enhanced Chemo/Photothermal Antitumor Activities. / Chen, Mi; Pérez, Roció L.; Du, Pu; Bhattarai, Nimisha; McDonough, Karen C.; Ravula, Sudhir; Kumar, Revati; Mathis, J. Michael; Warner, Isiah M.

In: ACS Applied Materials and Interfaces, Vol. 11, No. 31, 08.07.2019, p. 27548-27557.

Research output: Contribution to journalArticle

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T1 - Tumor-Targeting NIRF NanoGUMBOS with Cyclodextrin-Enhanced Chemo/Photothermal Antitumor Activities

AU - Chen, Mi

AU - Pérez, Roció L.

AU - Du, Pu

AU - Bhattarai, Nimisha

AU - McDonough, Karen C.

AU - Ravula, Sudhir

AU - Kumar, Revati

AU - Mathis, J. Michael

AU - Warner, Isiah M.

PY - 2019/7/8

Y1 - 2019/7/8

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KW - IR780

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