TY - JOUR
T1 - Tumor necrosis factor alpha (TNF-α) blockade improves natural killer cell (NK) activation, hypertension, and mitochondrial oxidative stress in a preclinical rat model of preeclampsia
AU - Cunningham, Mark W.
AU - Jayaram, Aswathi
AU - Deer, Evangeline
AU - Amaral, Lorena M.
AU - Vaka, Venkata Ramana
AU - Ibrahim, Tarek
AU - Cornelius, Denise C.
AU - LaMarca, Babbette
N1 - Funding Information:
This study was supported by NIH grant RO1HD067541 (BL), NIH grants R00HL130456 and P20GM104357 (DCC), NIH P20GM121334 (BL, LMA), American heart association (AHA) early career award 19CDA34670055 (LMA), and the AHA early career grant award 18CDA34110264 (MWCJr).
Publisher Copyright:
© 2020, © 2020 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2020
Y1 - 2020
N2 - The RUPP rat model of Preeclampsia exhibits hypertension (MAP), cytolytic natural killer (cNK) cells, tumor necrosis factor alpha (TNF-α) and mitochondrial Reactive Oxygen Species (mt ROS). Objective: Does TNF-α blockade with ETAN (Etanercept) decrease cNK cell and mt ROS in RUPP rats. Methods: On gestational day 14, RUPP surgery was performed, ETAN (0.4 mg/kg) was administered on day 18, MAP, blood and tissues collected on 19. Results:MAP, cytolytic NK cells and mt ROS were elevated in RUPP vs. NP and normalized with ETAN. Conclusion: TNF-α blockade lowered blood pressure and improve inflammation and organ function in response to placental ischemia.
AB - The RUPP rat model of Preeclampsia exhibits hypertension (MAP), cytolytic natural killer (cNK) cells, tumor necrosis factor alpha (TNF-α) and mitochondrial Reactive Oxygen Species (mt ROS). Objective: Does TNF-α blockade with ETAN (Etanercept) decrease cNK cell and mt ROS in RUPP rats. Methods: On gestational day 14, RUPP surgery was performed, ETAN (0.4 mg/kg) was administered on day 18, MAP, blood and tissues collected on 19. Results:MAP, cytolytic NK cells and mt ROS were elevated in RUPP vs. NP and normalized with ETAN. Conclusion: TNF-α blockade lowered blood pressure and improve inflammation and organ function in response to placental ischemia.
KW - Hypertension
KW - inflammation and oxidative stress
UR - http://www.scopus.com/inward/record.url?scp=85088169000&partnerID=8YFLogxK
U2 - 10.1080/10641955.2020.1793999
DO - 10.1080/10641955.2020.1793999
M3 - Article
C2 - 32646252
AN - SCOPUS:85088169000
SN - 1064-1955
SP - 399
EP - 404
JO - Hypertension in Pregnancy
JF - Hypertension in Pregnancy
ER -