Tumor necrosis factor alpha (TNF-α) blockade improves natural killer cell (NK) activation, hypertension, and mitochondrial oxidative stress in a preclinical rat model of preeclampsia

Mark W. Cunningham, Aswathi Jayaram, Evangeline Deer, Lorena M. Amaral, Venkata Ramana Vaka, Tarek Ibrahim, Denise C. Cornelius, Babbette LaMarca

Research output: Contribution to journalArticlepeer-review

Abstract

The RUPP rat model of Preeclampsia exhibits hypertension (MAP), cytolytic natural killer (cNK) cells, tumor necrosis factor alpha (TNF-α) and mitochondrial Reactive Oxygen Species (mt ROS).  Objective: Does TNF-α blockade with ETAN (Etanercept) decrease cNK cell and mt ROS in RUPP rats. Methods: On gestational day 14, RUPP surgery was performed, ETAN (0.4 mg/kg) was administered on day 18, MAP, blood and tissues collected on 19. Results:MAP, cytolytic NK cells and mt ROS were elevated in RUPP vs. NP and normalized with ETAN. Conclusion: TNF-α blockade lowered blood pressure and improve inflammation and organ function in response to placental ischemia.

Original languageEnglish
Pages (from-to)399-404
Number of pages6
JournalHypertension in Pregnancy
DOIs
StatePublished - 2020

Keywords

  • Hypertension
  • inflammation and oxidative stress

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