TRPC channels: Interacting proteins

K. Kiselyov, D. M. Shin, J. Y. Kim, Joseph P. Yuan, S. Muallem

Research output: Chapter in Book/Report/Conference proceedingChapter

25 Scopus citations

Abstract

TRP channels, in particular the TRPC and TRPV subfamilies, have emerged as important constituents of the receptor-activated Ca2+ influx mechanism triggered by hormones, growth factors, and neurotransmitters through activation of phospholipase C (PLC). Several TRPC channels are also activated by passive depletion of endoplasmic reticulum (ER) Ca2+. Although in several studies the native TRP channels faithfully reproduce the respective recombinant channels, more often the properties of Ca2+ entry and/or the store-operated current are strikingly different from that of the TRP channels expressed in the same cells. The present review aims to discuss this disparity in the context of interaction of TRPC channels with auxiliary proteins that may alter the permeation and regulation of TRPC channels.

Original languageEnglish
Title of host publicationTransient Receptor Potential (TRP) Channels
EditorsVeit Flockerzi, Bernd Nilius
Pages559-574
Number of pages16
DOIs
StatePublished - 1 Dec 2007

Publication series

NameHandbook of Experimental Pharmacology
Volume179
ISSN (Print)0171-2004
ISSN (Electronic)1865-0325

Keywords

  • Homer
  • Junctate
  • Receptor-induced Ca influx
  • Scaffold proteins
  • TRP channels

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    Kiselyov, K., Shin, D. M., Kim, J. Y., Yuan, J. P., & Muallem, S. (2007). TRPC channels: Interacting proteins. In V. Flockerzi, & B. Nilius (Eds.), Transient Receptor Potential (TRP) Channels (pp. 559-574). (Handbook of Experimental Pharmacology; Vol. 179). https://doi.org/10.1007/978-3-540-34891-7_33