Treatment with an orally bioavailable prodrug of 17β-estradiol alleviates hot flushes without hormonal effects in the periphery

Keyphrases

• 17-estradiol 100%
• Anterior pituitary 20%
• Beneficial Effects 20%
• Bioprecursor Prodrug 20%
• Brain Targeting 20%
• Breast 20%
• Breast Cancer Cells 20%
• Climacteric Symptoms 20%
• Diurnal Rhythm 20%
• Estradiol Therapy 20%
• Estrogen 60%
• Estrogen Deprivation 40%
• Estrogen Therapy 20%
• Female Brain 20%
• Hormonal Exposure 20%
• Hormonal Stimulation 100%
• Hot Flushes 100%
• Induced Loss 20%
• Morphine 20%
• Oral Administration 20%
• Orally Bioavailable 100%
• Ovariectomized Rat Model 20%
• Peripheral Organs 20%
• Preclinical Assessment 20%
• Prodrug 100%
• Rat Model 20%
• Tail Skin Temperature 40%
• Temperature Rise 20%
• Thermoregulatory Dysfunction 20%
• Unwanted Side Effects 20%
• Uterus 40%
• Xenograft 20%

Pharmacology, Toxicology and Pharmaceutical Science

• Breast Cancer 20%
• Diethylstilbestrol 100%
• Hot Flush 100%
• Menopausal Syndrome 20%
• Morphine 20%
• Prodrug 100%
• Rat Model 40%
• Side Effect 40%

Neuroscience

• Anterior Pituitary 33%
• Circadian Rhythm 33%
• Diethylstilbestrol 100%
• Morphine 33%
• Prodrug 100%