Abstract
Evolving knowledge of the underlying neurochemistry of treatment-resistant depression and associatedfunctional and structural changes in the brain is encouraging attempts with novel therapies. Therapeutic strategies include optimizing apartially successful initial treatment before trying something else, switching to a different drug within or outside of a class, combining agents with different mechanisms of action, and augmenting antidepressant treatment with a non-antidepressant drug. Clinicians need managed care access to a broad range of agents in order to choose the most appropriate therapy for eachpatient.
| Original language | English |
|---|---|
| Pages (from-to) | 12-16 |
| Number of pages | 5 |
| Journal | Psychiatric Times |
| Volume | 26 |
| Issue number | SUPPL. MAY |
| State | Published - May 2009 |
Keywords
- Augmentation strategies
- Switching strategies
- Treatment-resistant depression