Evolving knowledge of the underlying neurochemistry of treatment-resistant depression and associatedfunctional and structural changes in the brain is encouraging attempts with novel therapies. Therapeutic strategies include optimizing apartially successful initial treatment before trying something else, switching to a different drug within or outside of a class, combining agents with different mechanisms of action, and augmenting antidepressant treatment with a non-antidepressant drug. Clinicians need managed care access to a broad range of agents in order to choose the most appropriate therapy for eachpatient.
|Number of pages||5|
|Issue number||SUPPL. MAY|
|State||Published - 1 May 2009|
- Augmentation strategies
- Switching strategies
- Treatment-resistant depression