Treatment-resistant depression: Choosing from among pharmacological strategies

Lawrence J. Cohen

Research output: Contribution to journalArticlepeer-review


Evolving knowledge of the underlying neurochemistry of treatment-resistant depression and associatedfunctional and structural changes in the brain is encouraging attempts with novel therapies. Therapeutic strategies include optimizing apartially successful initial treatment before trying something else, switching to a different drug within or outside of a class, combining agents with different mechanisms of action, and augmenting antidepressant treatment with a non-antidepressant drug. Clinicians need managed care access to a broad range of agents in order to choose the most appropriate therapy for eachpatient.

Original languageEnglish
Pages (from-to)12-16
Number of pages5
JournalPsychiatric Times
Issue numberSUPPL. MAY
StatePublished - May 2009


  • Augmentation strategies
  • Switching strategies
  • Treatment-resistant depression


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