Transforming growth factor-beta2 utilizes the canonical Smad-signaling pathway to regulate tissue transglutaminase expression in human trabecular meshwork cells

Keyphrases

• Trabecular Meshwork Cells 100%
• Transforming Growth factor-β2 (TGF-β2) 100%
• Smad Signaling Pathway 100%
• Tissue Transglutaminase 100%
• TGM2 55%
• Trabecular Meshwork 33%
• Smad3 33%
• Glaucoma 16%
• Protein Level 16%
• Glaucomatous 16%
• Enzyme Activity 16%
• Signaling Pathway 11%
• Colocalization 11%
• Extracellular Matrix Protein 1 (ECM1) 11%
• Immunohistochemistry 11%
• Specific Inhibitor 11%
• Cell Strain 11%
• Protein Enzymes 11%
• SiRNA Knockdown 11%
• Expression Localization 11%
• Small Interfering RNA (siRNA) 5%
• Intraocular Pressure 5%
• Elevated Intraocular Pressure 5%
• Overexpression 5%
• Gene Expression 5%
• Phosphorylation 5%
• Growth Factors 5%
• Western Immunoblotting 5%
• Aqueous Humor 5%
• Human Trabecular Meshwork 5%
• Serum-free Medium 5%
• Immunoblot Analysis 5%
• Calcium-dependent 5%
• Biotin 5%
• Anterior Eye Segment 5%
• Extracellular Matrix Deposition 5%
• Primary Culture 5%
• Enzymatic Degradation 5%
• Activity Difference 5%
• Protein-resistant 5%
• Cadaverine 5%
• Physical Breakdown 5%
• Phospho-specific Antibodies 5%

Neuroscience

• Trabecular Meshwork 100%
• Cell Signaling 100%
• Protein Glutamine Gamma Glutamyltransferase 100%
• Transforming Growth Factor Beta2 100%
• Glaucoma 16%
• Small Interfering RNA 16%
• Enzyme Activity 16%
• CTGF 16%
• Intraocular Pressure 11%
• Immunohistochemistry 11%
• Extracellular Matrix Proteins 11%
• Protein Glutamine Gamma Glutamyltransferase 2 11%
• Gene Expression 5%
• Growth Factor 5%
• Extracellular Matrix 5%
• Aqueous Humor 5%
• Phosphospecific Antibody 5%
• Biotin 5%
• Primary Culture 5%
• Cadaverine 5%
• Immunoblotting 5%

Biochemistry, Genetics and Molecular Biology

• Signal Transduction 100%
• Tissue Transglutaminase 100%
• TGF Beta 2 100%
• Small Interfering RNA 16%
• Enzyme Activity 16%
• Connective Tissue Growth Factor 16%
• Intraocular Pressure 11%
• Extracellular Matrix Proteins 11%
• Scleroprotein 11%
• Gene Expression 5%
• Cross-Link 5%
• Enzyme 5%
• Humor 5%
• Growth Factor 5%
• Mediator 5%
• Primary Culture 5%
• Enzymatic Degradation 5%
• Immunoblotting 5%
• Antibodies 5%
• Biotin 5%