Transfer function analysis of dynamic cerebral autoregulation

A white paper from the International Cerebral Autoregulation Research Network

international Cerebral Autoregulation Research Network (CARNet)

Research output: Contribution to journalReview articleResearchpeer-review

93 Citations (Scopus)

Abstract

Cerebral autoregulation is the intrinsic ability of the brain to maintain adequate cerebral perfusion in the presence of blood pressure changes. A large number of methods to assess the quality of cerebral autoregulation have been proposed over the last 30 years. However, no single method has been universally accepted as a gold standard. Therefore, the choice of which method to employ to quantify cerebral autoregulation remains a matter of personal choice. Nevertheless, given the concept that cerebral autoregulation represents the dynamic relationship between blood pressure (stimulus or input) and cerebral blood flow (response or output), transfer function analysis became the most popular approach adopted in studies based on spontaneous fluctuations of blood pressure. Despite its sound theoretical background, the literature shows considerable variation in implementation of transfer function analysis in practice, which has limited comparisons between studies and hindered progress towards clinical application. Therefore, the purpose of the present white paper is to improve standardisation of parameters and settings adopted for application of transfer function analysis in studies of dynamic cerebral autoregulation. The development of these recommendations was initiated by (but not confined to) the Cerebral Autoregulation Research Network (CARNet - www.car-net.org).

Original languageEnglish
Pages (from-to)665-680
Number of pages16
JournalJournal of Cerebral Blood Flow and Metabolism
Volume36
Issue number4
DOIs
StatePublished - 1 Jan 2015

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Homeostasis
Research
Blood Pressure
Cerebrovascular Circulation
Perfusion
Brain

Keywords

  • Cerebral autoregulation
  • cerebral blood flow
  • gold standard
  • transfer function analysis
  • white paper

Cite this

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title = "Transfer function analysis of dynamic cerebral autoregulation: A white paper from the International Cerebral Autoregulation Research Network",
abstract = "Cerebral autoregulation is the intrinsic ability of the brain to maintain adequate cerebral perfusion in the presence of blood pressure changes. A large number of methods to assess the quality of cerebral autoregulation have been proposed over the last 30 years. However, no single method has been universally accepted as a gold standard. Therefore, the choice of which method to employ to quantify cerebral autoregulation remains a matter of personal choice. Nevertheless, given the concept that cerebral autoregulation represents the dynamic relationship between blood pressure (stimulus or input) and cerebral blood flow (response or output), transfer function analysis became the most popular approach adopted in studies based on spontaneous fluctuations of blood pressure. Despite its sound theoretical background, the literature shows considerable variation in implementation of transfer function analysis in practice, which has limited comparisons between studies and hindered progress towards clinical application. Therefore, the purpose of the present white paper is to improve standardisation of parameters and settings adopted for application of transfer function analysis in studies of dynamic cerebral autoregulation. The development of these recommendations was initiated by (but not confined to) the Cerebral Autoregulation Research Network (CARNet - www.car-net.org).",
keywords = "Cerebral autoregulation, cerebral blood flow, gold standard, transfer function analysis, white paper",
author = "{international Cerebral Autoregulation Research Network (CARNet)} and Claassen, {Jurgen Ahr} and {Meel-Van Den Abeelen}, {Aisha Ss} and Simpson, {David M.} and Panerai, {Ronney B.} and {Alexander Caicedo Dorado}, {Caicedo Dorado} and Mitsis, {Georgios D.} and Patrice Brassard and Ainslie, {Philip N.} and Paul Summers and Kenichi Iwasaki and Arminas Ragauskas and Tzeng, {Yu Chieh} and Martin M{\"u}ller and Wang, {Cheng Yen} and Hu, {Han Hwa} and {Meel-Van Den Abeelen}, {Aisha S.S.} and Erik Gommer and Karemaker, {John M.} and Marcel Aries and {Van Lieshout}, {Johannes J.} and Vladimir Semenyuti and Vugar Aliev and John Potter and Peter Smielewski and Xiuyun Liu and Marek Czosnyka and Stephen Payne and Damian Bailey and Bernardo Yelicich and Corina Puppo and Dae Shin and Rickards, {Caroline A.} and Rickards, {Caroline Alice} and Rong Zhang and Vasilis Marmarelis and Vera Novak",
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Transfer function analysis of dynamic cerebral autoregulation : A white paper from the International Cerebral Autoregulation Research Network. / international Cerebral Autoregulation Research Network (CARNet).

In: Journal of Cerebral Blood Flow and Metabolism, Vol. 36, No. 4, 01.01.2015, p. 665-680.

Research output: Contribution to journalReview articleResearchpeer-review

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T2 - A white paper from the International Cerebral Autoregulation Research Network

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AU - Brassard, Patrice

AU - Ainslie, Philip N.

AU - Summers, Paul

AU - Iwasaki, Kenichi

AU - Ragauskas, Arminas

AU - Tzeng, Yu Chieh

AU - Müller, Martin

AU - Wang, Cheng Yen

AU - Hu, Han Hwa

AU - Meel-Van Den Abeelen, Aisha S.S.

AU - Gommer, Erik

AU - Karemaker, John M.

AU - Aries, Marcel

AU - Van Lieshout, Johannes J.

AU - Semenyuti, Vladimir

AU - Aliev, Vugar

AU - Potter, John

AU - Smielewski, Peter

AU - Liu, Xiuyun

AU - Czosnyka, Marek

AU - Payne, Stephen

AU - Bailey, Damian

AU - Yelicich, Bernardo

AU - Puppo, Corina

AU - Shin, Dae

AU - Rickards, Caroline A.

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AU - Zhang, Rong

AU - Marmarelis, Vasilis

AU - Novak, Vera

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KW - transfer function analysis

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