TY - JOUR
T1 - Transdermal delivery of methotrexate for pediatrics using silicon microneedles
AU - Abla, Mehtab J.
AU - Chaturvedula, Ayyappa
AU - O'Mahony, Conor
AU - Banga, Ajay K.
PY - 2013/5/1
Y1 - 2013/5/1
N2 - Background: The objective of this work was to study transdermal delivery of methotrexate using silicon microneedles and simulate plasma concentrations using a population pharmacokinetic model. Results: Characterization of silicon microneedles was carried out by scanning electron microscopy, transepidermal water loss, methylene blue staining, calcein imaging, pore permeability index and confocal microscopy, which confirmed the formation of microchannels. In vitro permeation studies were performed to study the enhancement in transdermal delivery following microporation. Conclusion: Simulation data demonstrated that with 16, 64, 128 and 192 microneedles, mean plasma concentrations of 0.3, 1.4, 2.8 and 4.2 ng/ml, respectively, can be achieved. Thus, therapeutically relevant doses could be delivered in pediatrics by increasing the number of microneedles and patch area.
AB - Background: The objective of this work was to study transdermal delivery of methotrexate using silicon microneedles and simulate plasma concentrations using a population pharmacokinetic model. Results: Characterization of silicon microneedles was carried out by scanning electron microscopy, transepidermal water loss, methylene blue staining, calcein imaging, pore permeability index and confocal microscopy, which confirmed the formation of microchannels. In vitro permeation studies were performed to study the enhancement in transdermal delivery following microporation. Conclusion: Simulation data demonstrated that with 16, 64, 128 and 192 microneedles, mean plasma concentrations of 0.3, 1.4, 2.8 and 4.2 ng/ml, respectively, can be achieved. Thus, therapeutically relevant doses could be delivered in pediatrics by increasing the number of microneedles and patch area.
UR - http://www.scopus.com/inward/record.url?scp=84877650064&partnerID=8YFLogxK
U2 - 10.4155/tde.13.24
DO - 10.4155/tde.13.24
M3 - Article
C2 - 23647273
AN - SCOPUS:84877650064
SN - 2041-5990
VL - 4
SP - 543
EP - 551
JO - Therapeutic Delivery
JF - Therapeutic Delivery
IS - 5
ER -