TP53 germline variations influence the predisposition and prognosis of b-cell acute lymphoblastic leukemia in children

Keyphrases

• Acute Lymphoblastic Leukemia 100%
• Tumor Protein p53 (TP53) 100%
• B Cells 100%
• Childhood Acute Lymphoblastic Leukemia 100%
• Germline Variation 100%
• TP53 Variants 50%
• Germ Cells 40%
• TP53 Pathogenic Variant 40%
• Hypodiploidy 20%
• Non-acute 20%
• Li-Fraumeni Syndrome 20%
• Odds Ratio 10%
• Transcriptional Activity 10%
• Clinical Significance 10%
• High Risk 10%
• Loss Function 10%
• Leukemia Diagnosis 10%
• Pathogenic Variants 10%
• Cumulative Incidence 10%
• Genetic Basis 10%
• Targeted Sequencing 10%
• In Silico Prediction 10%
• Second Cancer 10%
• Control Population 10%
• Coding Region 10%
• Clinical Trials 10%
• Leukaemia Clinical 10%
• Treatment Outcome 10%
• Damaging Effects 10%
• Leukemia 10%
• Coding Variants 10%
• Event-free Survival 10%
• In(III) 10%
• Adverse Clinical Outcomes 10%
• Second Malignant Neoplasm 10%
• Overall Survival 10%
• Variant Pathogenicity 10%
• Penetrant 10%
• Hazard Ratio 10%
• Children's Oncology Group 10%
• Cancer Predisposition 10%
• Leukemia Therapy 10%

Biochemistry, Genetics and Molecular Biology

• Germline 100%
• Germ Cell 100%
• Prevalence 40%
• Clinical Trial 20%
• Coding Region 20%
• Event Free Survival 20%
• Overall Survival 20%
• Genetics 20%