Total Synthesis of (+)-laurencin: An Asymmetric Alkylation - Ring-closing Metathesis Approach to Medium Ring Ethers

Medicine & Life Sciences

• laurencin 100%
• Ethers 64%
• Alkenes 63%
• Oxazolidinones 62%
• glycolic acid 57%
• Alkylation 54%
• Biological Products 40%
• 4-benzyl-3-benzyloxyacetyl-2-oxazolidinone 6%

Physics & Astronomy

• metathesis 68%
• alkylation 67%
• closing 46%
• ethers 45%
• synthesis 29%
• rings 27%
• alkenes 17%
• routes 11%
• products 8%
• matrices 7%

Chemical Compounds

• Glycolate 54%
• Oxazolidinone 52%
• Olefin Metathesis 50%
• Ring Closing Metathesis 47%
• Total Synthesis 35%
• Alkylation 34%
• Ether 27%