Abstract
(Matrix resented) The enantioselective total synthesis of (+)-laurencin 1 is achieved in 18 steps from (S)-(+)-4-benzyl-3-benzyloxyacetyl-2-oxazolidinone. The key steps in this synthesis are an asymmetric glycolate alkylation leading to acyl oxazolidinone 2 and a subsequent ring-closing olefin metathesis to construct the oxocene core of 1. The approach to medium ring ethers utilized in this synthesis provides a general and efficient route to the cyclic core of other marine natural products.
Original language | English |
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Pages (from-to) | 2029-2032 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 1 |
Issue number | 12 |
DOIs | |
State | Published - 16 Dec 1999 |