Abstract
(Chemical Equation Presented) A total synthesis of brevetoxin A is reported. Two tetracyclic coupling partners, prepared from previously reported advanced fragments, were effectively united via a Horner-Wittig olefination. The resulting octacycle was progressed to substrates that were explored for reductive etherification, the success of which led to a penultimate tetraol intermediate. The tetraol was converted to the natural product through an expeditious selective oxidative process followed by methylenation.
Original language | English |
---|---|
Pages (from-to) | 489-492 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 11 |
Issue number | 2 |
DOIs | |
State | Published - 15 Jan 2009 |