TY - JOUR
T1 - Toll-like receptors in the vascular system
T2 - Sensing the dangers within
AU - Goulopoulou, Styliani
AU - McCarthy, Cameron G.
AU - Clinton Webb, R.
N1 - Publisher Copyright:
© 2015 by The American Society for Pharmacology and Experimental Therapeutics.
PY - 2016
Y1 - 2016
N2 - Toll-like receptors (TLRs) are components of the innate immune system that respond to exogenous infectious ligands (pathogen-associated molecular patterns, PAMPs) and endogenous molecules that are released during host tissue injury/death (damageassociated molecular patterns, DAMPs). Interaction of TLRs with their ligands leads to activation of downstream signaling pathways that induce an immune response by producing inflammatory cytokines, type Iinterferons (IFN), and other inflammatory mediators. TLRactivation affects vascular function and remodeling,0 and these molecular events prime antigen-specific.
AB - Toll-like receptors (TLRs) are components of the innate immune system that respond to exogenous infectious ligands (pathogen-associated molecular patterns, PAMPs) and endogenous molecules that are released during host tissue injury/death (damageassociated molecular patterns, DAMPs). Interaction of TLRs with their ligands leads to activation of downstream signaling pathways that induce an immune response by producing inflammatory cytokines, type Iinterferons (IFN), and other inflammatory mediators. TLRactivation affects vascular function and remodeling,0 and these molecular events prime antigen-specific.
UR - http://www.scopus.com/inward/record.url?scp=84955098041&partnerID=8YFLogxK
U2 - 10.1124/pr.114.010090
DO - 10.1124/pr.114.010090
M3 - Article
C2 - 26721702
AN - SCOPUS:84955098041
SN - 0031-6997
VL - 68
SP - 142
EP - 167
JO - Pharmacological Reviews
JF - Pharmacological Reviews
IS - 1
ER -