TY - JOUR
T1 - Tissue hemoglobin monitoring of progressive central hypovolemia in humans using broadband diffuse optical spectroscopy
AU - Lee, Jangwoen
AU - Kim, Jae G.
AU - Mahon, Sari
AU - Tromberg, Bruce J.
AU - Ryan, Kathy L.
AU - Convertino, Victor A.
AU - Rickards, Caroline A.
AU - Osann, Kathryn
AU - Brenner, Matthew
N1 - Funding Information:
The authors thank the subjects for their cheerful cooperation, and Gary Muniz for his engineering and technical assistance during the experiments. This research was supported by funding from the United States Army Medical Research and Materiel Command Combat Casualty Research Program, AF-9550-04-1-0101, FOS-2004-0011A and 0012A, and LAMMP 445474-30136.
PY - 2008
Y1 - 2008
N2 - We demonstrate noninvasive near-infrared diffuse optical spectroscopy (DOS) measurements of tissue hemoglobin contents that can track progressive reductions in central blood volume in human volunteers. Measurements of mean arterial blood pressure (MAP), heart rate (HR), stroke volume (SV), and cardiac output (Q) are obtained in ten healthy human subjects during baseline supine rest and exposure to progressive reductions of central blood volume produced by application of lower body negative pressure (LBNP). Simultaneous quantitative noninvasive measurements of tissue oxyhemoglobin (OHb), deoxyhemoglobin (RHb), total hemoglobin concentration (THb), and tissue hemoglobin oxygen saturation (S tO 2) are performed throughout LBNP application using broadband DOS. As progressively increasing amounts of LBNP are applied, HR increases, and MAP, SV, and Q decrease (p<0.001). OHb, S tO 2, and THb decrease (p <0.001) in correlation with progressive increases in LBNP, while tissue RHb remained relatively constant (p = 0.378). The average fractional changes from baseline values in DOS OHb (fOHb) correlate closely with independently measured changes in SV (r 2 = 0.95) and Q (r 2 = 0.98) during LBNP. Quantitative noninvasive broadband DOS measurements of tissue hemoglobin parameters of peripheral perfusion are capable of detecting progressive reductions in central blood volume, and appear to be sensitive markers of early hypoperfusion associated with hemorrhage as simulated by LBNP.
AB - We demonstrate noninvasive near-infrared diffuse optical spectroscopy (DOS) measurements of tissue hemoglobin contents that can track progressive reductions in central blood volume in human volunteers. Measurements of mean arterial blood pressure (MAP), heart rate (HR), stroke volume (SV), and cardiac output (Q) are obtained in ten healthy human subjects during baseline supine rest and exposure to progressive reductions of central blood volume produced by application of lower body negative pressure (LBNP). Simultaneous quantitative noninvasive measurements of tissue oxyhemoglobin (OHb), deoxyhemoglobin (RHb), total hemoglobin concentration (THb), and tissue hemoglobin oxygen saturation (S tO 2) are performed throughout LBNP application using broadband DOS. As progressively increasing amounts of LBNP are applied, HR increases, and MAP, SV, and Q decrease (p<0.001). OHb, S tO 2, and THb decrease (p <0.001) in correlation with progressive increases in LBNP, while tissue RHb remained relatively constant (p = 0.378). The average fractional changes from baseline values in DOS OHb (fOHb) correlate closely with independently measured changes in SV (r 2 = 0.95) and Q (r 2 = 0.98) during LBNP. Quantitative noninvasive broadband DOS measurements of tissue hemoglobin parameters of peripheral perfusion are capable of detecting progressive reductions in central blood volume, and appear to be sensitive markers of early hypoperfusion associated with hemorrhage as simulated by LBNP.
KW - Hemodynamic decompensation
KW - Hemorrhagic shock
KW - Lower body negative pressure
UR - http://www.scopus.com/inward/record.url?scp=62449267414&partnerID=8YFLogxK
U2 - 10.1117/1.3041712
DO - 10.1117/1.3041712
M3 - Article
C2 - 19123673
AN - SCOPUS:62449267414
SN - 1083-3668
VL - 13
JO - Journal of Biomedical Optics
JF - Journal of Biomedical Optics
IS - 6
M1 - 064027
ER -