Tip110/SART3 regulates IL-8 expression and predicts the clinical outcomes in melanoma

Khalid Amine Timani, Balázs Gyorffy, Ying Liu, Khalid S. Mohammad, Johnny J. He

Research output: Contribution to journalLetterpeer-review

14 Scopus citations


Tip110, an important regulator of several oncogenic proteins, was significantly downregulated in human metastatic melanoma cells exposed to a hypoxic condition. Therefore, in this study, we set to determine whether differential expression of Tip110 could be an important indicator for melanoma tumorigenesis and metastasis. We found that in melanoma, but not in other cancer types, Tip110 knockdown enhanced significant expression and secretion of IL-8 and melanoma cells invasions. This induction was further potentiated under hypoxia and by inflammatory cytokine and found independent of TNF-α autocrine signaling. We further showed that Tip110 knockdown-mediated IL-8 induction involved IL-8 mRNA stability. Furthermore, the transcriptomic profiling data and survival from 455 melanoma patients demonstrated that the correlation between Tip110 expression and the clinical outcomes in melanoma was stage-dependent. These findings uncover important roles of Tip110 in melanoma tumorigenesis and metastasis through regulation of IL-8 and hope to provide new clues for future therapeutic strategies.

Original languageEnglish
Article number124
JournalMolecular Cancer
Issue number1
StatePublished - 17 Aug 2018


  • Hypoxia
  • IL-8
  • Melanoma
  • TP53, NF-ΚB
  • Tip110/SART3


Dive into the research topics of 'Tip110/SART3 regulates IL-8 expression and predicts the clinical outcomes in melanoma'. Together they form a unique fingerprint.

Cite this