Tip110: Physical properties, primary structure, and biological functions

Amanda Whitmill, Khalid Amine Timani, Ying Liu, Johnny J. He

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations


HIV-1 Tat-interacting protein of 110 kDa (Tip110), also referred to as squamous cell carcinoma antigen recognized by T cells 3 (Sart3), p110 or p110nrb, was initially identified as a cDNA clone (KIAA0156) without annotated functions. Over the past twenty years, several functions have been attributed to this protein. The proposed biological functions include roles for Tip110 in pre-mRNA splicing, gene transcription, stem cell biology, and development. Dysregulation of Tip110 is also a contributing factor in the development of cancer and other human diseases. It is clear that our understanding of this protein is rapidly evolving. In this review, we aimed to provide a summary of all the existing literature on this gene/protein and its proposed biological functions.

Original languageEnglish
Pages (from-to)79-95
Number of pages17
JournalLife Sciences
StatePublished - 15 Mar 2016


  • Development
  • Gene transcription
  • HIV replication
  • Post-translational modifications
  • Pre-mRNA splicing
  • Stem cell biology
  • Tip110


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