Tip110

Physical properties, primary structure, and biological functions

Research output: Contribution to journalReview articleResearchpeer-review

7 Citations (Scopus)

Abstract

HIV-1 Tat-interacting protein of 110 kDa (Tip110), also referred to as squamous cell carcinoma antigen recognized by T cells 3 (Sart3), p110 or p110nrb, was initially identified as a cDNA clone (KIAA0156) without annotated functions. Over the past twenty years, several functions have been attributed to this protein. The proposed biological functions include roles for Tip110 in pre-mRNA splicing, gene transcription, stem cell biology, and development. Dysregulation of Tip110 is also a contributing factor in the development of cancer and other human diseases. It is clear that our understanding of this protein is rapidly evolving. In this review, we aimed to provide a summary of all the existing literature on this gene/protein and its proposed biological functions.

Original languageEnglish
Pages (from-to)79-95
Number of pages17
JournalLife Sciences
Volume149
DOIs
StatePublished - 15 Mar 2016

Fingerprint

tat Gene Products
Physical properties
Proteins
RNA Precursors
Cell Biology
HIV-1
Stem Cells
Complementary DNA
Clone Cells
Cytology
T-Lymphocytes
T-cells
Transcription
Stem cells
Genes
Neoplasms

Keywords

  • Development
  • Gene transcription
  • HIV replication
  • Post-translational modifications
  • Pre-mRNA splicing
  • Stem cell biology
  • Tip110

Cite this

@article{e8fcb282d1184c05a4d0b0a797276d9e,
title = "Tip110: Physical properties, primary structure, and biological functions",
abstract = "HIV-1 Tat-interacting protein of 110 kDa (Tip110), also referred to as squamous cell carcinoma antigen recognized by T cells 3 (Sart3), p110 or p110nrb, was initially identified as a cDNA clone (KIAA0156) without annotated functions. Over the past twenty years, several functions have been attributed to this protein. The proposed biological functions include roles for Tip110 in pre-mRNA splicing, gene transcription, stem cell biology, and development. Dysregulation of Tip110 is also a contributing factor in the development of cancer and other human diseases. It is clear that our understanding of this protein is rapidly evolving. In this review, we aimed to provide a summary of all the existing literature on this gene/protein and its proposed biological functions.",
keywords = "Development, Gene transcription, HIV replication, Post-translational modifications, Pre-mRNA splicing, Stem cell biology, Tip110",
author = "Amanda Whitmill and Timani, {Khalid A.} and Ying Liu and He, {Johnny Jianglin}",
year = "2016",
month = "3",
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doi = "10.1016/j.lfs.2016.02.062",
language = "English",
volume = "149",
pages = "79--95",
journal = "Life Sciences",
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publisher = "Elsevier Inc.",

}

Tip110 : Physical properties, primary structure, and biological functions. / Whitmill, Amanda; Timani, Khalid A.; Liu, Ying; He, Johnny Jianglin.

In: Life Sciences, Vol. 149, 15.03.2016, p. 79-95.

Research output: Contribution to journalReview articleResearchpeer-review

TY - JOUR

T1 - Tip110

T2 - Physical properties, primary structure, and biological functions

AU - Whitmill, Amanda

AU - Timani, Khalid A.

AU - Liu, Ying

AU - He, Johnny Jianglin

PY - 2016/3/15

Y1 - 2016/3/15

N2 - HIV-1 Tat-interacting protein of 110 kDa (Tip110), also referred to as squamous cell carcinoma antigen recognized by T cells 3 (Sart3), p110 or p110nrb, was initially identified as a cDNA clone (KIAA0156) without annotated functions. Over the past twenty years, several functions have been attributed to this protein. The proposed biological functions include roles for Tip110 in pre-mRNA splicing, gene transcription, stem cell biology, and development. Dysregulation of Tip110 is also a contributing factor in the development of cancer and other human diseases. It is clear that our understanding of this protein is rapidly evolving. In this review, we aimed to provide a summary of all the existing literature on this gene/protein and its proposed biological functions.

AB - HIV-1 Tat-interacting protein of 110 kDa (Tip110), also referred to as squamous cell carcinoma antigen recognized by T cells 3 (Sart3), p110 or p110nrb, was initially identified as a cDNA clone (KIAA0156) without annotated functions. Over the past twenty years, several functions have been attributed to this protein. The proposed biological functions include roles for Tip110 in pre-mRNA splicing, gene transcription, stem cell biology, and development. Dysregulation of Tip110 is also a contributing factor in the development of cancer and other human diseases. It is clear that our understanding of this protein is rapidly evolving. In this review, we aimed to provide a summary of all the existing literature on this gene/protein and its proposed biological functions.

KW - Development

KW - Gene transcription

KW - HIV replication

KW - Post-translational modifications

KW - Pre-mRNA splicing

KW - Stem cell biology

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SN - 0024-3205

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