Abstract
HIV-1 Tat-interacting protein of 110 kDa (Tip110), also referred to as squamous cell carcinoma antigen recognized by T cells 3 (Sart3), p110 or p110nrb, was initially identified as a cDNA clone (KIAA0156) without annotated functions. Over the past twenty years, several functions have been attributed to this protein. The proposed biological functions include roles for Tip110 in pre-mRNA splicing, gene transcription, stem cell biology, and development. Dysregulation of Tip110 is also a contributing factor in the development of cancer and other human diseases. It is clear that our understanding of this protein is rapidly evolving. In this review, we aimed to provide a summary of all the existing literature on this gene/protein and its proposed biological functions.
Original language | English |
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Pages (from-to) | 79-95 |
Number of pages | 17 |
Journal | Life Sciences |
Volume | 149 |
DOIs | |
State | Published - 15 Mar 2016 |
Keywords
- Development
- Gene transcription
- HIV replication
- Post-translational modifications
- Pre-mRNA splicing
- Stem cell biology
- Tip110