Tip110: Physical properties, primary structure, and biological functions

Amanda Whitmill; Khalid Amine Timani; Ying Liu; Johnny J. He

doi:10.1016/j.lfs.2016.02.062

Tip110: Physical properties, primary structure, and biological functions

Amanda Whitmill, Khalid Amine Timani, Ying Liu, Johnny J. He

Microbiology, Immunology & Genetics

Research output: Contribution to journal › Review article › peer-review

14 Scopus citations

Abstract

HIV-1 Tat-interacting protein of 110 kDa (Tip110), also referred to as squamous cell carcinoma antigen recognized by T cells 3 (Sart3), p110 or p110^nrb, was initially identified as a cDNA clone (KIAA0156) without annotated functions. Over the past twenty years, several functions have been attributed to this protein. The proposed biological functions include roles for Tip110 in pre-mRNA splicing, gene transcription, stem cell biology, and development. Dysregulation of Tip110 is also a contributing factor in the development of cancer and other human diseases. It is clear that our understanding of this protein is rapidly evolving. In this review, we aimed to provide a summary of all the existing literature on this gene/protein and its proposed biological functions.

Original language	English
Pages (from-to)	79-95
Number of pages	17
Journal	Life Sciences
Volume	149
DOIs	https://doi.org/10.1016/j.lfs.2016.02.062
State	Published - 15 Mar 2016

Keywords

Development
Gene transcription
HIV replication
Post-translational modifications
Pre-mRNA splicing
Stem cell biology
Tip110

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10.1016/j.lfs.2016.02.062

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title = "Tip110: Physical properties, primary structure, and biological functions",

abstract = "HIV-1 Tat-interacting protein of 110 kDa (Tip110), also referred to as squamous cell carcinoma antigen recognized by T cells 3 (Sart3), p110 or p110nrb, was initially identified as a cDNA clone (KIAA0156) without annotated functions. Over the past twenty years, several functions have been attributed to this protein. The proposed biological functions include roles for Tip110 in pre-mRNA splicing, gene transcription, stem cell biology, and development. Dysregulation of Tip110 is also a contributing factor in the development of cancer and other human diseases. It is clear that our understanding of this protein is rapidly evolving. In this review, we aimed to provide a summary of all the existing literature on this gene/protein and its proposed biological functions.",

keywords = "Development, Gene transcription, HIV replication, Post-translational modifications, Pre-mRNA splicing, Stem cell biology, Tip110",

author = "Amanda Whitmill and Timani, {Khalid Amine} and Ying Liu and He, {Johnny J.}",

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AU - Whitmill, Amanda

AU - Timani, Khalid Amine

AU - Liu, Ying

AU - He, Johnny J.

PY - 2016/3/15

Y1 - 2016/3/15

N2 - HIV-1 Tat-interacting protein of 110 kDa (Tip110), also referred to as squamous cell carcinoma antigen recognized by T cells 3 (Sart3), p110 or p110nrb, was initially identified as a cDNA clone (KIAA0156) without annotated functions. Over the past twenty years, several functions have been attributed to this protein. The proposed biological functions include roles for Tip110 in pre-mRNA splicing, gene transcription, stem cell biology, and development. Dysregulation of Tip110 is also a contributing factor in the development of cancer and other human diseases. It is clear that our understanding of this protein is rapidly evolving. In this review, we aimed to provide a summary of all the existing literature on this gene/protein and its proposed biological functions.

AB - HIV-1 Tat-interacting protein of 110 kDa (Tip110), also referred to as squamous cell carcinoma antigen recognized by T cells 3 (Sart3), p110 or p110nrb, was initially identified as a cDNA clone (KIAA0156) without annotated functions. Over the past twenty years, several functions have been attributed to this protein. The proposed biological functions include roles for Tip110 in pre-mRNA splicing, gene transcription, stem cell biology, and development. Dysregulation of Tip110 is also a contributing factor in the development of cancer and other human diseases. It is clear that our understanding of this protein is rapidly evolving. In this review, we aimed to provide a summary of all the existing literature on this gene/protein and its proposed biological functions.

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KW - Gene transcription

KW - HIV replication

KW - Post-translational modifications

KW - Pre-mRNA splicing

KW - Stem cell biology

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DO - 10.1016/j.lfs.2016.02.062

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Tip110: Physical properties, primary structure, and biological functions

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Keywords

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