Tip110 maintains expression of pluripotent factors in and pluripotency of human embryonic stem cells

Ying Liu, Man Ryul Lee, Khalid A. Timani, Johnny Jianglin He, Hal E. Broxmeyer

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Abstract

HIV-1 Tat-interacting protein of 110kDa [Tip110; p110(nrb)/SART3/p110] is an RNA binding nuclear protein implicated in regulation of HIV-1 gene and host gene transcription, pre-mRNA splicing, and cancer immunology. Recently, we demonstrated a role for Tip110 in regulation of hematopoiesis. Here, we show that TIP110 is also expressed in human embryonic stem cells (hESCs) and expression was decreased with differentiation of these ESCs. TIP110 was found, through up- and down-modulation of expression of Tip110, to be important in maintaining pluripotent factor (NANOG, OCT4, and SOX2) expression in and pluripotency of hESCs, although the mechanisms involved and whether the Tip110 effects are direct remain to be determined.

Original languageEnglish
Pages (from-to)829-833
Number of pages5
JournalStem Cells and Development
Volume21
Issue number6
DOIs
StatePublished - 10 Apr 2012

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HIV-1
tat Gene Products
RNA-Binding Proteins
RNA Precursors
Hematopoiesis
Nuclear Proteins
Allergy and Immunology
Genes
Neoplasms
Human Embryonic Stem Cells

Cite this

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title = "Tip110 maintains expression of pluripotent factors in and pluripotency of human embryonic stem cells",
abstract = "HIV-1 Tat-interacting protein of 110kDa [Tip110; p110(nrb)/SART3/p110] is an RNA binding nuclear protein implicated in regulation of HIV-1 gene and host gene transcription, pre-mRNA splicing, and cancer immunology. Recently, we demonstrated a role for Tip110 in regulation of hematopoiesis. Here, we show that TIP110 is also expressed in human embryonic stem cells (hESCs) and expression was decreased with differentiation of these ESCs. TIP110 was found, through up- and down-modulation of expression of Tip110, to be important in maintaining pluripotent factor (NANOG, OCT4, and SOX2) expression in and pluripotency of hESCs, although the mechanisms involved and whether the Tip110 effects are direct remain to be determined.",
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Tip110 maintains expression of pluripotent factors in and pluripotency of human embryonic stem cells. / Liu, Ying; Lee, Man Ryul; Timani, Khalid A.; He, Johnny Jianglin; Broxmeyer, Hal E.

In: Stem Cells and Development, Vol. 21, No. 6, 10.04.2012, p. 829-833.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Tip110 maintains expression of pluripotent factors in and pluripotency of human embryonic stem cells

AU - Liu, Ying

AU - Lee, Man Ryul

AU - Timani, Khalid A.

AU - He, Johnny Jianglin

AU - Broxmeyer, Hal E.

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AB - HIV-1 Tat-interacting protein of 110kDa [Tip110; p110(nrb)/SART3/p110] is an RNA binding nuclear protein implicated in regulation of HIV-1 gene and host gene transcription, pre-mRNA splicing, and cancer immunology. Recently, we demonstrated a role for Tip110 in regulation of hematopoiesis. Here, we show that TIP110 is also expressed in human embryonic stem cells (hESCs) and expression was decreased with differentiation of these ESCs. TIP110 was found, through up- and down-modulation of expression of Tip110, to be important in maintaining pluripotent factor (NANOG, OCT4, and SOX2) expression in and pluripotency of hESCs, although the mechanisms involved and whether the Tip110 effects are direct remain to be determined.

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