TY - JOUR
T1 - Tip110 maintains expression of pluripotent factors in and pluripotency of human embryonic stem cells
AU - Liu, Ying
AU - Lee, Man Ryul
AU - Timani, Khalid
AU - He, Johnny J.
AU - Broxmeyer, Hal E.
PY - 2012/4/10
Y1 - 2012/4/10
N2 - HIV-1 Tat-interacting protein of 110kDa [Tip110; p110(nrb)/SART3/p110] is an RNA binding nuclear protein implicated in regulation of HIV-1 gene and host gene transcription, pre-mRNA splicing, and cancer immunology. Recently, we demonstrated a role for Tip110 in regulation of hematopoiesis. Here, we show that TIP110 is also expressed in human embryonic stem cells (hESCs) and expression was decreased with differentiation of these ESCs. TIP110 was found, through up- and down-modulation of expression of Tip110, to be important in maintaining pluripotent factor (NANOG, OCT4, and SOX2) expression in and pluripotency of hESCs, although the mechanisms involved and whether the Tip110 effects are direct remain to be determined.
AB - HIV-1 Tat-interacting protein of 110kDa [Tip110; p110(nrb)/SART3/p110] is an RNA binding nuclear protein implicated in regulation of HIV-1 gene and host gene transcription, pre-mRNA splicing, and cancer immunology. Recently, we demonstrated a role for Tip110 in regulation of hematopoiesis. Here, we show that TIP110 is also expressed in human embryonic stem cells (hESCs) and expression was decreased with differentiation of these ESCs. TIP110 was found, through up- and down-modulation of expression of Tip110, to be important in maintaining pluripotent factor (NANOG, OCT4, and SOX2) expression in and pluripotency of hESCs, although the mechanisms involved and whether the Tip110 effects are direct remain to be determined.
UR - http://www.scopus.com/inward/record.url?scp=84859378635&partnerID=8YFLogxK
U2 - 10.1089/scd.2011.0512
DO - 10.1089/scd.2011.0512
M3 - Article
C2 - 22132941
AN - SCOPUS:84859378635
SN - 1547-3287
VL - 21
SP - 829
EP - 833
JO - Stem Cells and Development
JF - Stem Cells and Development
IS - 6
ER -