@article{17e758b0f0104d36b5f40054353bf8a6,
title = "Thermodynamic Surface Analyses to Inform Biofilm Resistance",
abstract = "Biofilms are the habitat of 95% of bacteria successfully protecting bacteria from many antibiotics. However, inhibiting biofilm formation is difficult in that it is a complex system involving the physical and chemical interaction of both substrate and bacteria. Focusing on the substrate surface and potential interactions with bacteria, we examined both physical and chemical properties of substrates coated with a series of phenyl acrylate monomer derivatives. Atomic force microscopy (AFM) showed smooth surfaces often approximating surgical grade steel. Induced biofilm growth of five separate bacteria on copolymer samples comprising varying concentrations of phenyl acrylate monomer derivatives evidenced differing degrees of biofilm resistance via optical microscopy. Using goniometric surface analyses, the van Oss-Chaudhury-Good equation was solved linear algebraically to determine the surface energy profile of each polymerized phenyl acrylate monomer derivative, two bacteria, and collagen. Based on the microscopy and surface energy profiles, a thermodynamic explanation for biofilm resistance is posited.",
keywords = "Microbiology, Polymer Chemistry, Thermodynamics",
author = "Cavitt, {T. Brian} and Carlisle, {Jasmine G.} and Dodds, {Alexandra R.} and Faulkner, {Rebecca A.} and Garfield, {Tyson C.} and Ghebranious, {Verena N.} and Hendley, {Phillip R.} and Henry, {Emily B.} and Holt, {Charles J.} and Lowe, {Jordan R.} and Lowry, {Jacob A.} and Oskin, {D. Spencer} and Patel, {Pooja R.} and Devin Smith and Wenting Wei",
note = "Funding Information: The authors would like to thank the Albemarle Corporation for providing DMPA and Allied Photochemical for providing the standard industrial formulation used. We would also like to gratefully acknowledge the financial support of The Welch Foundation (Grant R-0021 ), the Abilene Christian University Office of Research and Sponsored Programs, and Lipscomb University 's Office of the Provost and Department of Chemistry and Biochemistry. Funding Information: The authors would like to thank the Albemarle Corporation for providing DMPA and Allied Photochemical for providing the standard industrial formulation used. We would also like to gratefully acknowledge the financial support of The Welch Foundation (Grant R-0021), the Abilene Christian University Office of Research and Sponsored Programs, and Lipscomb University's Office of the Provost and Department of Chemistry and Biochemistry. Conceptualization, T.B.C.; Methodology, T.B.C. J.G.C. R.A.F. C.J.H. J.R.L. D.S.O. and D.S.; Validation, T.B.C.; Formal Analysis, T.B.C. J.G.C. V.N.G. D.S.O. and P.R.P.; Investigation, J.G.C. A.R.D. R.A.F. T.C.G. V.N.G. P.R.H. E.B.H. C.J.H. J.R.L. J.A.L. D.S.O. P.R.P. D.S. and W.W.; Resources, T.B.C.; Data Curation, T.B.C. J.G.C. V.N.G. D.S.O. and P.R.P.; Writing ? Original Draft, T.B.C.; Writing ? Review & Editing, T.B.C.; Visualization, T.B.C.; Supervision, T.B.C.; Project Administration, T.B.C.; Funding Acquisition, T.B.C. The Lead Contact and a coauthor have two patents related to the research herein (Cavitt and Faulkner, 2015, 2017). The authors declare no other competing interest. Publisher Copyright: {\textcopyright} 2020 The Author(s)",
year = "2020",
month = nov,
day = "20",
doi = "10.1016/j.isci.2020.101702",
language = "English",
volume = "23",
journal = "iScience",
issn = "2589-0042",
publisher = "Elsevier Inc.",
number = "11",
}