Therapeutics of 5-HT3 receptor antagonists: Current uses and future directions

Research output: Contribution to journalReview article

48 Citations (Scopus)

Abstract

The 5-Hydroxytryptamine3 (5-HT3) receptor is a member of the cys-loop family of ligand gated ion channels, of which the nicotinic acetylcholine receptor is the prototype. All other 5-HT receptors identified to date are metabotropic receptors. The 5-HT3 receptor is present in the central and peripheral nervous systems, as well as a number of non-nervous tissues. As an ion channel that is permeable to the cations, Na+, K+, and Ca2+, the 5-HT3 receptor mediates fast depolarizing responses in pre- and post-synaptic neurons. As such, 5-HT 3 receptor antagonists that are used clinically block afferent and efferent synaptic transmission. The most well established physiological roles of the 5-HT3 receptor are to coordinate emesis and regulate gastrointestinal motility. Currently marketed 5-HT3 receptor antagonists are indicated for the treatment of chemotherapy, radiation, and anesthesia-induced nausea and vomiting, as well as irritable bowel syndrome. Other therapeutic uses that have been explored include pain and drug addiction. The 5-HT3 receptor is one of a number of receptors that play a role in mediating nausea and vomiting, and as such, 5-HT3 receptor antagonists demonstrate the greatest anti-emetic efficacy when administered in combination with other drug classes.

Original languageEnglish
Pages (from-to)338-347
Number of pages10
JournalPharmacology and Therapeutics
Volume130
Issue number3
DOIs
StatePublished - 1 Jan 2011

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Vomiting
Serotonin Receptors
Nausea
Ligand-Gated Ion Channels
Gastrointestinal Motility
Antiemetics
Irritable Bowel Syndrome
Peripheral Nervous System
Nicotinic Receptors
Therapeutic Uses
Ion Channels
Synaptic Transmission
Substance-Related Disorders
Cations
Therapeutics
Anesthesia
Central Nervous System
Radiation
Neurons
Drug Therapy

Keywords

  • 5-HT
  • Antagonist
  • Irritable bowel syndrome
  • Nausea and vomiting
  • Serotonin

Cite this

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Therapeutics of 5-HT3 receptor antagonists : Current uses and future directions. / Machu, Tina K.

In: Pharmacology and Therapeutics, Vol. 130, No. 3, 01.01.2011, p. 338-347.

Research output: Contribution to journalReview article

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