Therapeutic potential of cancer stem cells

Chunguang Yang, Kunlin Jin, Yangping Tong, William Chi Cho

Research output: Contribution to journalReview article

17 Citations (Scopus)

Abstract

Cancer stem cells (CSCs) play an important role in cancer growth, self-renewal, metastasis, recurrence and radio/chemotherapy. However, the underlying mechanisms remain elusive. In this review, we explore the roles of CSCs in cancer’s relapse and progression and discuss the biomarkers of CSCs to predict clinical outcome and their diagnostic potential. The different approaches of CSC therapies are also reviewed, including cytotoxic, radiation, differentiation and targeting signaling pathways. We also discuss the challenge of targeting CSCs in cancer therapy. In addition, non-coding RNAs in CSC therapies are also discussed.

Original languageEnglish
JournalMedical Oncology
Volume32
Issue number6
DOIs
StatePublished - 1 May 2015

Fingerprint

Neoplastic Stem Cells
Cell- and Tissue-Based Therapy
Therapeutics
Recurrence
Neoplasms
Untranslated RNA
Radio
Biomarkers
Radiation
Neoplasm Metastasis
Drug Therapy
Growth

Keywords

  • Cancer stem cells
  • Epithelial–mesenchymal transition
  • Signaling pathway
  • Therapeutics

Cite this

Yang, Chunguang ; Jin, Kunlin ; Tong, Yangping ; Cho, William Chi. / Therapeutic potential of cancer stem cells. In: Medical Oncology. 2015 ; Vol. 32, No. 6.
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Therapeutic potential of cancer stem cells. / Yang, Chunguang; Jin, Kunlin; Tong, Yangping; Cho, William Chi.

In: Medical Oncology, Vol. 32, No. 6, 01.05.2015.

Research output: Contribution to journalReview article

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AU - Cho, William Chi

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