Therapeutic potential of cancer stem cells

Chunguang Yang; Kunlin Jin; Yangping Tong; William Chi Cho

doi:10.1007/s12032-015-0619-6

Therapeutic potential of cancer stem cells

Chunguang Yang, Kunlin Jin, Yangping Tong, William Chi Cho

Research output: Contribution to journal › Review article › peer-review

19 Scopus citations

Abstract

Cancer stem cells (CSCs) play an important role in cancer growth, self-renewal, metastasis, recurrence and radio/chemotherapy. However, the underlying mechanisms remain elusive. In this review, we explore the roles of CSCs in cancer’s relapse and progression and discuss the biomarkers of CSCs to predict clinical outcome and their diagnostic potential. The different approaches of CSC therapies are also reviewed, including cytotoxic, radiation, differentiation and targeting signaling pathways. We also discuss the challenge of targeting CSCs in cancer therapy. In addition, non-coding RNAs in CSC therapies are also discussed.

Original language	English
Journal	Medical Oncology
Volume	32
Issue number	6
DOIs	https://doi.org/10.1007/s12032-015-0619-6
State	Published - 1 May 2015

Keywords

Cancer stem cells
Epithelial–mesenchymal transition
Signaling pathway
Therapeutics

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10.1007/s12032-015-0619-6

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title = "Therapeutic potential of cancer stem cells",

abstract = "Cancer stem cells (CSCs) play an important role in cancer growth, self-renewal, metastasis, recurrence and radio/chemotherapy. However, the underlying mechanisms remain elusive. In this review, we explore the roles of CSCs in cancer{\textquoteright}s relapse and progression and discuss the biomarkers of CSCs to predict clinical outcome and their diagnostic potential. The different approaches of CSC therapies are also reviewed, including cytotoxic, radiation, differentiation and targeting signaling pathways. We also discuss the challenge of targeting CSCs in cancer therapy. In addition, non-coding RNAs in CSC therapies are also discussed.",

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AU - Yang, Chunguang

AU - Jin, Kunlin

AU - Tong, Yangping

AU - Cho, William Chi

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N2 - Cancer stem cells (CSCs) play an important role in cancer growth, self-renewal, metastasis, recurrence and radio/chemotherapy. However, the underlying mechanisms remain elusive. In this review, we explore the roles of CSCs in cancer’s relapse and progression and discuss the biomarkers of CSCs to predict clinical outcome and their diagnostic potential. The different approaches of CSC therapies are also reviewed, including cytotoxic, radiation, differentiation and targeting signaling pathways. We also discuss the challenge of targeting CSCs in cancer therapy. In addition, non-coding RNAs in CSC therapies are also discussed.

AB - Cancer stem cells (CSCs) play an important role in cancer growth, self-renewal, metastasis, recurrence and radio/chemotherapy. However, the underlying mechanisms remain elusive. In this review, we explore the roles of CSCs in cancer’s relapse and progression and discuss the biomarkers of CSCs to predict clinical outcome and their diagnostic potential. The different approaches of CSC therapies are also reviewed, including cytotoxic, radiation, differentiation and targeting signaling pathways. We also discuss the challenge of targeting CSCs in cancer therapy. In addition, non-coding RNAs in CSC therapies are also discussed.

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KW - Epithelial–mesenchymal transition

KW - Signaling pathway

KW - Therapeutics

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VL - 32

JO - Medical Oncology

JF - Medical Oncology

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Therapeutic potential of cancer stem cells

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Keywords

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