Therapeutic potential of cancer stem cells

Chunguang Yang, Kunlin Jin, Yangping Tong, William Chi Cho

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations

Abstract

Cancer stem cells (CSCs) play an important role in cancer growth, self-renewal, metastasis, recurrence and radio/chemotherapy. However, the underlying mechanisms remain elusive. In this review, we explore the roles of CSCs in cancer’s relapse and progression and discuss the biomarkers of CSCs to predict clinical outcome and their diagnostic potential. The different approaches of CSC therapies are also reviewed, including cytotoxic, radiation, differentiation and targeting signaling pathways. We also discuss the challenge of targeting CSCs in cancer therapy. In addition, non-coding RNAs in CSC therapies are also discussed.

Original languageEnglish
JournalMedical Oncology
Volume32
Issue number6
DOIs
StatePublished - 1 May 2015

Keywords

  • Cancer stem cells
  • Epithelial–mesenchymal transition
  • Signaling pathway
  • Therapeutics

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