Therapeutic implications of cancer stem cell: Challenges and opportunities in translational studies

Chunguang Yang; Kunlin Jin; Yue Zhang; Hong Sun; William C. Cho

doi:10.1007/978-3-319-21030-8_19

Therapeutic implications of cancer stem cell: Challenges and opportunities in translational studies

Chunguang Yang, Kunlin Jin, Yue Zhang, Hong Sun, William C. Cho

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Cancer stem cells (CSCs) are rare in cancer population, but they can reconstruct the whole bulk of tumor if most of the cancer cells are killed by radiotherapy or chemotherapy. However, the mechanism of CSCs’ self-renewal, regeneration and therapeutic resistance is still unknown. Here we discuss the role of CSCs in cancer relapse and progression, as well as their diagnostic and therapeutic potentials. We also confer the biomarkers in pre-clinical models and clinical trials to evaluate the therapeutic effectiveness of CSCs. In addition, we discuss the potential therapeutic strategies of eradicating CSCs in tumors, such as cytotoxic, radiation, signaling pathway and differentiation therapies.

Original language	English
Title of host publication	Cancer Stem Cells
Subtitle of host publication	Emerging Concepts and Future Perspectives in Translational Oncology
Publisher	Springer International Publishing
Pages	533-553
Number of pages	21
ISBN (Electronic)	9783319210308
ISBN (Print)	9783319210292
DOIs	https://doi.org/10.1007/978-3-319-21030-8_19
State	Published - 1 Jan 2015

Keywords

Biomarkers
Cancer stem cells
Clinical outcome
Clinical trials
Diagnosis
Therapy

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10.1007/978-3-319-21030-8_19

Cite this

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abstract = "Cancer stem cells (CSCs) are rare in cancer population, but they can reconstruct the whole bulk of tumor if most of the cancer cells are killed by radiotherapy or chemotherapy. However, the mechanism of CSCs{\textquoteright} self-renewal, regeneration and therapeutic resistance is still unknown. Here we discuss the role of CSCs in cancer relapse and progression, as well as their diagnostic and therapeutic potentials. We also confer the biomarkers in pre-clinical models and clinical trials to evaluate the therapeutic effectiveness of CSCs. In addition, we discuss the potential therapeutic strategies of eradicating CSCs in tumors, such as cytotoxic, radiation, signaling pathway and differentiation therapies.",

keywords = "Biomarkers, Cancer stem cells, Clinical outcome, Clinical trials, Diagnosis, Therapy",

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Therapeutic implications of cancer stem cell: Challenges and opportunities in translational studies. / Yang, Chunguang; Jin, Kunlin; Zhang, Yue et al.
Cancer Stem Cells: Emerging Concepts and Future Perspectives in Translational Oncology. Springer International Publishing, 2015. p. 533-553.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

TY - CHAP

T1 - Therapeutic implications of cancer stem cell

T2 - Challenges and opportunities in translational studies

AU - Yang, Chunguang

AU - Jin, Kunlin

AU - Zhang, Yue

AU - Sun, Hong

AU - Cho, William C.

N1 - Publisher Copyright: © Springer International Publishing Switzerland 2015.

PY - 2015/1/1

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AB - Cancer stem cells (CSCs) are rare in cancer population, but they can reconstruct the whole bulk of tumor if most of the cancer cells are killed by radiotherapy or chemotherapy. However, the mechanism of CSCs’ self-renewal, regeneration and therapeutic resistance is still unknown. Here we discuss the role of CSCs in cancer relapse and progression, as well as their diagnostic and therapeutic potentials. We also confer the biomarkers in pre-clinical models and clinical trials to evaluate the therapeutic effectiveness of CSCs. In addition, we discuss the potential therapeutic strategies of eradicating CSCs in tumors, such as cytotoxic, radiation, signaling pathway and differentiation therapies.

KW - Biomarkers

KW - Cancer stem cells

KW - Clinical outcome

KW - Clinical trials

KW - Diagnosis

KW - Therapy

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SP - 533

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BT - Cancer Stem Cells

PB - Springer International Publishing

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Therapeutic implications of cancer stem cell: Challenges and opportunities in translational studies

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Keywords

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