Abstract
Cancer stem cells (CSCs) are rare in cancer population, but they can reconstruct the whole bulk of tumor if most of the cancer cells are killed by radiotherapy or chemotherapy. However, the mechanism of CSCs’ self-renewal, regeneration and therapeutic resistance is still unknown. Here we discuss the role of CSCs in cancer relapse and progression, as well as their diagnostic and therapeutic potentials. We also confer the biomarkers in pre-clinical models and clinical trials to evaluate the therapeutic effectiveness of CSCs. In addition, we discuss the potential therapeutic strategies of eradicating CSCs in tumors, such as cytotoxic, radiation, signaling pathway and differentiation therapies.
Original language | English |
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Title of host publication | Cancer Stem Cells |
Subtitle of host publication | Emerging Concepts and Future Perspectives in Translational Oncology |
Publisher | Springer International Publishing |
Pages | 533-553 |
Number of pages | 21 |
ISBN (Electronic) | 9783319210308 |
ISBN (Print) | 9783319210292 |
DOIs | |
State | Published - 1 Jan 2015 |
Keywords
- Biomarkers
- Cancer stem cells
- Clinical outcome
- Clinical trials
- Diagnosis
- Therapy