Therapeutic implications of cancer stem cell: Challenges and opportunities in translational studies

Chunguang Yang, Kunlin Jin, Yue Zhang, Hong Sun, William C. Cho

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Cancer stem cells (CSCs) are rare in cancer population, but they can reconstruct the whole bulk of tumor if most of the cancer cells are killed by radiotherapy or chemotherapy. However, the mechanism of CSCs’ self-renewal, regeneration and therapeutic resistance is still unknown. Here we discuss the role of CSCs in cancer relapse and progression, as well as their diagnostic and therapeutic potentials. We also confer the biomarkers in pre-clinical models and clinical trials to evaluate the therapeutic effectiveness of CSCs. In addition, we discuss the potential therapeutic strategies of eradicating CSCs in tumors, such as cytotoxic, radiation, signaling pathway and differentiation therapies.

Original languageEnglish
Title of host publicationCancer Stem Cells
Subtitle of host publicationEmerging Concepts and Future Perspectives in Translational Oncology
PublisherSpringer International Publishing
Pages533-553
Number of pages21
ISBN (Electronic)9783319210308
ISBN (Print)9783319210292
DOIs
StatePublished - 1 Jan 2015

Fingerprint

Neoplastic Stem Cells
Stem cells
Neoplasms
Tumors
Therapeutics
Chemotherapy
Radiotherapy
Biomarkers
Regeneration
Cells
Clinical Trials
Radiation
Recurrence
Drug Therapy
Population

Keywords

  • Biomarkers
  • Cancer stem cells
  • Clinical outcome
  • Clinical trials
  • Diagnosis
  • Therapy

Cite this

Yang, C., Jin, K., Zhang, Y., Sun, H., & Cho, W. C. (2015). Therapeutic implications of cancer stem cell: Challenges and opportunities in translational studies. In Cancer Stem Cells: Emerging Concepts and Future Perspectives in Translational Oncology (pp. 533-553). Springer International Publishing. https://doi.org/10.1007/978-3-319-21030-8_19
Yang, Chunguang ; Jin, Kunlin ; Zhang, Yue ; Sun, Hong ; Cho, William C. / Therapeutic implications of cancer stem cell : Challenges and opportunities in translational studies. Cancer Stem Cells: Emerging Concepts and Future Perspectives in Translational Oncology. Springer International Publishing, 2015. pp. 533-553
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Yang, C, Jin, K, Zhang, Y, Sun, H & Cho, WC 2015, Therapeutic implications of cancer stem cell: Challenges and opportunities in translational studies. in Cancer Stem Cells: Emerging Concepts and Future Perspectives in Translational Oncology. Springer International Publishing, pp. 533-553. https://doi.org/10.1007/978-3-319-21030-8_19

Therapeutic implications of cancer stem cell : Challenges and opportunities in translational studies. / Yang, Chunguang; Jin, Kunlin; Zhang, Yue; Sun, Hong; Cho, William C.

Cancer Stem Cells: Emerging Concepts and Future Perspectives in Translational Oncology. Springer International Publishing, 2015. p. 533-553.

Research output: Chapter in Book/Report/Conference proceedingChapter

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T2 - Challenges and opportunities in translational studies

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AB - Cancer stem cells (CSCs) are rare in cancer population, but they can reconstruct the whole bulk of tumor if most of the cancer cells are killed by radiotherapy or chemotherapy. However, the mechanism of CSCs’ self-renewal, regeneration and therapeutic resistance is still unknown. Here we discuss the role of CSCs in cancer relapse and progression, as well as their diagnostic and therapeutic potentials. We also confer the biomarkers in pre-clinical models and clinical trials to evaluate the therapeutic effectiveness of CSCs. In addition, we discuss the potential therapeutic strategies of eradicating CSCs in tumors, such as cytotoxic, radiation, signaling pathway and differentiation therapies.

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Yang C, Jin K, Zhang Y, Sun H, Cho WC. Therapeutic implications of cancer stem cell: Challenges and opportunities in translational studies. In Cancer Stem Cells: Emerging Concepts and Future Perspectives in Translational Oncology. Springer International Publishing. 2015. p. 533-553 https://doi.org/10.1007/978-3-319-21030-8_19